PROSPR Statistical Coordinating Center (PSCC)

PROSPR 统计协调中心 (PSCC)

• 批准号: 9456913
• 负责人: WILLIAM E BARLOW
• 金额: $ 78.15万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9456913
• 关键词: Breast Cancer Detection; Breast Cancer Surveillance Consortium; Clinic; Clinical; Collaborations; Colon Carcinoma; Communication; Communities; Consultations; Data; Data Analyses; Data Collection; Data Coordinating Center; Diagnosis; Early Detection Research Network; Epidemiology; Funding; Health Care Costs; Instruction; Lead; Leadership; Logistics; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Meta-Analysis; Methodology; Mission; Organ; Population Research; Process; Productivity; Recruitment Activity; Regimen; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Screening for cancer; Secure; Site; Talents; Universities; Washington; anticancer research; data management; design; experience; improved; malignant breast neoplasm; meetings; mortality; operation; outreach; programs; screening; statistics; success; web portal; working group

The success of the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) program critically relies on a highly talented and committed PROSPR Statistical Coordinating Center (PSCC) to coordinate the research of PROSPR Research Centers (PRCs) to achieve PROSPR's mission of evaluating and improving the cancer screening process (recruitment, screening, diagnosis, and referral for treatment). This PSCC application is from a team of investigators with extensive experience in statistics, data and coordinating center management, and research focused on the screening of breast, colon, and cervical cancers at the Fred Hutchinson Cancer Research (FHCRC) and University of Washington (UW), built upon the infrastructure and expertises from three large NCI-funded coordinating centers over multiple funding cycles: the Early Detection Research Network (EDRN), Breast Cancer Surveillance Consortium (BCSC), and the Transdisciplinary Research on Energetics and Cancer (TREC) Consortium. The overall objectives of the PSCC are to be accomplished by 1) Providing logistic support for PROSPR meetings and enhance communications and collaborations via a secure PROSPR web portal and a dedicated operations team; 2) Providing scientific, clinical, and statistical leadership to enhance PROSPR's scientific vigor and productivity via three organ specific PSCC working groups with the extensive expertise in statistics, clinics, and epidemiology; 3) Providing study design, data collection, and data management expertise to enable appropriate pooling of data from studies across PRCs and to lead trans-network cross organ site studies via a statistical team with extensive experience in developing new statistical methodology and in designing and analyzing data for screening studies; 4) Providing statistical consultations for PRCs and lead data analyses for pooled PROSPR studies and trans-network studies; and 5) Serving as a resource to the scientific community for dissemination and outreach of PROSPR data and findings via a PROSPR public portal. RELEVANCE (See instructions): Improving screening process for breast, colon, and cervical cancers will reduce mortality, motbidity, and health care cost associated with these cancers in US.

个体化方案优化筛查人群研究的成功 (PROSPR)项目在很大程度上依赖于才华横溢、尽职尽责的PROSPR统计协调 中心(PSCC)协调PROSPR研究中心(PRCs)的研究以实现PROSPR 评估和改进癌症筛查过程的任务(招募、筛查、诊断和 转介治疗)。此PSCC应用程序来自一组具有丰富经验的调查人员 统计、数据和协调中心管理，研究重点是乳房筛查， 弗雷德·哈钦森癌症研究中心(FHCRC)和华盛顿大学的结肠癌和宫颈癌 华盛顿(UW)，建立在NCI资助的三家大型协调机构的基础设施和专业知识的基础上 多个资助周期的中心：早期检测研究网络(EDRN)，乳腺癌 监测联盟(BCSC)和能量学与癌症跨学科研究(TREC) 财团。 PSCC的总体目标是通过1)为PROSPR提供后勤支持来实现 通过安全的PROSPR Web门户和 专职运营团队；2)提供科学、临床和统计领导，以增强PROSPR 通过三个特定器官的PSCC工作组提供科学活力和生产力，这些工作组拥有广泛的 统计、临床和流行病学；3)提供研究设计、数据收集和数据管理 专业知识，以实现跨区域研究的适当数据池，并引领跨网络 通过在开发新的统计方法方面具有丰富经验的统计团队进行的器官位置研究 为筛查研究设计和分析数据；4)为区域中心提供统计咨询 以及联合PROSPR研究和跨网络研究的主导数据分析；以及5)作为资源 通过PROSPR向科学界传播和推广PROSPR数据和研究结果 公共门户。 相关性(请参阅说明)： 改进乳腺癌、结肠癌和宫颈癌的筛查程序将降低死亡率、发病率和 在美国，与这些癌症相关的医疗费用。

项目成果

Oxidative stress and lung function.

氧化应激和肺功能。

• DOI: 10.1093/oxfordjournals.aje.a009220
• 发表时间: 1997
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Schünemann,HJ;Muti,P;Freudenheim,JL;Armstrong,D;Browne,R;Klocke,RA;Trevisan,M
• 通讯作者: Trevisan,M