PROSPR Statistical Coordinating Center (PSCC)

PROSPR 统计协调中心 (PSCC)

• 批准号: 8737203
• 负责人: WILLIAM E BARLOW
• 金额: $ 126.11万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-19 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8737203
• 关键词: Breast Cancer Detection; Breast Cancer Surveillance Consortium; Clinic; Clinical; Collaborations; Colon Carcinoma; Commit; Communication; Communities; Consultations; Data; Data Analyses; Data Collection; Data Coordinating Center; Diagnosis; Early Detection Research Network; Epidemiology; Funding; Health Care Costs; Instruction; Internet; Lead; Leadership; Logistics; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Meta-Analysis; Methodology; Mission; Organ; Process; Productivity; Regimen; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Screening for cancer; Secure; Site; Universities; Washington; anticancer research; data management; design; experience; improved; malignant breast neoplasm; meetings; mortality; operation; outreach; population based; programs; screening; statistics; success; working group

The success of the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) program critically relies on a highly talented and committed PROSPR Statistical Coordinating Center (PSCC) to coordinate the research of PROSPR Research Centers (PRCs) to achieve PROSPR's mission of evaluating and improving the cancer screening process (recruitment, screening, diagnosis, and referral for treatment). This PSCC application is from a team of investigators with extensive experience in statistics, data and coordinating center management, and research focused on the screening of breast, colon, and cervical cancers at the Fred Hutchinson Cancer Research (FHCRC) and University of Washington (UW), built upon the infrastructure and expertises from three large NCI-funded coordinating centers over multiple funding cycles: the Early Detection Research Network (EDRN), Breast Cancer Surveillance Consortium (BCSC), and the Transdisciplinary Research on Energetics and Cancer (TREC) Consortium. The overall objectives of the PSCC are to be accomplished by 1) Providing logistic support for PROSPR meetings and enhance communications and collaborations via a secure PROSPR web portal and a dedicated operations team; 2) Providing scientific, clinical, and statistical leadership to enhance PROSPR's scientific vigor and productivity via three organ specific PSCC working groups with the extensive expertise in statistics, clinics, and epidemiology; 3) Providing study design, data collection, and data management expertise to enable appropriate pooling of data from studies across PRCs and to lead trans-network cross organ site studies via a statistical team with extensive experience in developing new statistical methodology and in designing and analyzing data for screening studies; 4) Providing statistical consultations for PRCs and lead data analyses for pooled PROSPR studies and trans-network studies; and 5) Serving as a resource to the scientific community for dissemination and outreach of PROSPR data and findings via a PROSPR public portal. RELEVANCE (See instructions): Improving screening process for breast, colon, and cervical cancers will reduce mortality, motbidity, and health care cost associated with these cancers in US.

以人群为基础的研究通过个性化方案优化筛选的成功 （PROSPR）计划严重依赖于一个非常有才华和承诺PROSPR统计协调 中心（PSCC）协调PROSPR研究中心（PRCs）的研究，以实现PROSPR的 评估和改进癌症筛查过程（招募、筛查、诊断和 转诊治疗）。此PSCC应用程序来自一个具有丰富经验的研究团队， 统计、数据和协调中心管理，以及以乳腺癌筛查为重点的研究， 弗雷德哈钦森癌症研究中心（FHCRC）和弗吉尼亚大学的 华盛顿（UW），建立在基础设施和专业知识，从三个大型国家癌症研究所资助的协调 多个资助周期的中心：早期检测研究网络（EDRN），乳腺癌 能源学与癌症跨学科研究（Transdisciplinary Research on Energetics and Cancer，TREC） 财团 PSCC的总体目标将通过以下方式实现：1）为PROSPR提供后勤支持 会议，并通过安全的PROSPR门户网站和 专门的运营团队; 2）提供科学，临床和统计领导，以提高PROSPR的 通过三个器官特异性PSCC工作组的科学活力和生产力， 统计学、临床和流行病学; 3）提供研究设计、数据收集和数据管理 专业知识，以便能够适当汇集来自PRC研究的数据，并领导跨网络交叉 通过在开发新统计方法方面具有丰富经验的统计团队进行器官部位研究 为筛选研究设计和分析数据; 4）为PRC提供统计咨询 以及汇总PROSPR研究和跨网络研究的主要数据分析;以及5）作为资源 向科学界提供PROSPR数据和调查结果的传播和推广 公共门户。 相关性（参见说明）： 改善乳腺癌、结肠癌和宫颈癌的筛查过程将降低死亡率、死亡率和死亡率。 美国与这些癌症相关的医疗保健费用。