Free-Living Physical Activity and Energy Expenditure

自由生活的体力活动和能量消耗

• 批准号: 6531278
• 负责人: CAROL N BOOZER
• 金额: $ 14.43万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6531278
• 关键词: African American; adipose tissue; adolescence (12-20); bioenergetics; biosensor device; body composition; body physical activity; calorimetry; caucasian American; clinical research; controlled environment chamber; disease /disorder onset; female; gait; human subject; monitoring device; nutrient intake activity; obesity; patient oriented research; racial /ethnic difference; reproductive development; respiratory airflow measurement

DESCRIPTION (provided by applicant): The current epidemic of obesity in the United States and much of the rest of the world may be related to the decreased physical activity (PA) characteristic of modem life. Definition of the specific relationship of PA and obesity has been hampered by inadequate PA assessment methodology. We have recently validated a newly available PA measurement device (IDEEA) and found it to detect type, duration and intensity of many types of PA at better than 98% accuracy. We propose to use this device to describe specific PA of adolescent girls. But prior to beginning that study, we will further evaluate IDEEA to determine if it can also be used to accurately assess energy expenditure (EE). We will do this by validating it against the gold standards for EE measurement - respirometry indirect calorimetry and doubly labeled water. Specifically, we will compare IDEEA-derived estimates for EE, with: 1) EE measured for specific PA by hood respirometry, 2) EE measured by 24-hour chamber respirometry, and 3) free-living EE assessed by doubly labeled water. We will then use IDEEA to collect cross-sectional data on free-living PA and EE in adolescent girls. We choose this group because adolescence is a critical period for development of obesity, particularly in females. Adolescent obesity tracks not only with adult obesity, but also with other risk factors independent of adult weight. This is also the period of racial divergence in adiposity. We will therefore use this device to assess type, duration and intensity of PA and EE in free-living Caucasian and African-American girls, ages 11-16. Body composition (fat mass and fat-free mass) will then be modeled as a function of age, ethnicity, sexual maturation (Tanner stage) and specific free-living physical activities and associated EE. Findings from these studies will provide critical validation of this important new PA measurement device to the research community. They will also provide a far more complete description of PA in adolescent girls than has ever been possible before. Finally, data from these studies will provide the basis for a future application to conduct a longitudinal, PA intervention study in this population.

描述（由申请人提供）：美国和世界其他大部分地区的肥胖症当前流行可能与现代寿命的体育锻炼（PA）特征降低有关。 PA和肥胖的特定关系的定义因PA评估方法不足而受到阻碍。我们最近验证了新的PA测量设备（IDEEA），并发现它可以检测到许多类型的PA的类型，持续时间和强度，其精度优于98％。我们建议使用此设备来描述青春期女孩的特定PA。但是在开始研究之前，我们将进一步评估IDEEA，以确定是否也可以使用它来准确评估能量支出（EE）。我们将通过根据EE测量的黄金标准来验证它 - 呼吸量表间接量热法和双重标记的水。具体而言，我们将比较IDEEA衍生的EE的估计值，其中：1）通过hood呼吸测定法测量了特定PA的EE，2）EE通过24小时腔室呼吸测定法和3）通过双重标记的水评估的自由生活EE。然后，我们将使用IDEEA在青少年女孩中收集有关自由生活PA和EE的横断面数据。我们之所以选择这个组，是因为青春期是肥胖发展的关键时期，尤其是在女性中。青少年肥胖不仅与成人肥胖有关，而且还与其他危险因素无关，而与成人体重无关。这也是肥胖的种族差异时期。因此，我们将使用该设备评估11-16岁的自由生活高加索和非裔美国女孩中PA和EE的类型，持续时间和强度。然后，身体成分（脂肪质量和无脂肪质量）将被建模为年龄，种族，性成熟（坦纳阶段）和特定自由生活的体育活动以及相关的EE的函数。这些研究的发现将为研究社区提供对这一重要的新PA测量设备的批判性验证。他们还将为青少年女孩提供比以往任何时候都更完整的PA描述。最后，这些研究的数据将为将来的应用提供基础，以对该人群进行纵向，PA干预研究。