20 YEAR CHANGES IN FITNESS & CARDIOVASCULAR DISEASE RISK

20年健身变化

• 批准号: 7017724
• 负责人: Stephen Sidney
• 金额: $ 206.86万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7017724
• 关键词: African American; adipose tissue; adolescence (12-20); aerobic exercise; body composition; cardiovascular disorder; cardiovascular disorder risk; caucasian American; clinical research; coronary disorder; gender difference; genetic polymorphism; human middle age (35-64); human subject; hypertension; longitudinal human study; metabolic syndrome; noninsulin dependent diabetes mellitus; obesity; oxygen consumption; photon absorptiometry; physical fitness; racial /ethnic difference; young adult human (21-34)

DESCRIPTION (provided by applicant): Although an age-related decline in aerobic capacity is well documented, the impact of physical activity, body fat, and genetic variation on the rate of change is not well understood. In addition, little is known about how rate of change in aerobic capacity during early and middle adulthood affects the development of cardiovascular disease risk factors or the incidence of subclinical and clinical cardiovascular disease (CVD) related end-points. We propose to address these issues by conducting an ancillary study in conjunction with the Year 20 CARDIA (Coronary Artery Risk Development in Young Adults) examination, which is scheduled to take place beginning in June, 2005. We anticipate that approximately 3,650 (75%) of the surviving members of the initial cohort of African American and white men and women will return for the Year 20 exam, at which point they will be 38-50 years old. The overall goal of the proposed ancillary study is to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and sub-clinical CVD. To accomplish this goal, we propose to measure, on all Year 20 CARDIA participants: 1. Aerobic capacity, by means of a symptom-limited graded exercise treadmill test, using the same protocol as that used in CARDIA at the Year 0 and Year 7 exams; 2. Body composition and fat distribution, using a whole body dual energy x-ray absorptiometery (DEXA) scan; 3. Physical activity, using 7 days of accelerometer recordings; and 4. DNA sequence variants in selected candidate genes associated with cardiorespiratory fitness, components of the metabolic syndrome, and response to regular exercise, using stored DNA. Data from this ancillary study will be combined with core CARDIA examination data to address the following aims: a. Examination of the contribution of body mass and composition, fat distribution, objectively measured physical activity and specific genetic polymorphisms to the variance in Year 20 aerobic capacity and in age-related decline in aerobic capacity over a 20-year time period from young adulthood to mid-life, stratifying by race and gender. b. Longitudinal examination of the effect of aerobic capacity on changes in cardiovascular disease risk factors and on the incidence of CVD-related endpoints (e.g. hypertension, metabolic syndrome, subclinical disease [e.g. coronary artery calcium]). Data from this study should provide information that will help us more deeply understand the interrelationships of cardiorespiratory fitness, body composition, and CVD-related risk factors and endpoints, and may provide the basis for more extensive evidence-based recommendations on the role of fitness in cardiovascular health.

描述（由申请人提供）：尽管有氧能力与年龄相关的下降已有充分记录，但体力活动、身体脂肪和遗传变异对变化率的影响尚不清楚。此外，人们对成年早期和中期有氧能力的变化率如何影响心血管疾病危险因素的发展或亚临床和临床心血管疾病（CVD）相关终点的发生率知之甚少。我们建议通过结合 20 年 CARDIA（年轻人冠状动脉风险发展）检查（计划于 2005 年 6 月开始进行）进行一项辅助研究来解决这些问题。我们预计第一批非裔美国人和白人男性和女性中大约 3,650 名（75%）的幸存成员将返回参加 20 年检查，届时他们的年龄将在 38-50 岁。拟议辅助研究的总体目标是了解身体素质、体力活动、体重和成分以及脂肪分布、遗传因素之间复杂的纵向关系及其对肥胖、代谢综合征和亚临床心血管疾病发展的独立或相互作用的影响。为了实现这一目标，我们建议对所有 20 年 CARDIA 参与者进行衡量： 1. 有氧能力，通过症状限制分级运动跑步机测试，使用与 CARDIA 在 0 年级和 7 年级考试中使用的相同方案； 2.身体成分和脂肪分布，采用全身双能X射线吸收仪（DEXA）扫描； 3.体力活动，使用7天的加速度计记录；和 4. 使用储存的 DNA，确定与心肺健康、代谢综合征的组成部分以及对定期运动的反应相关的选定候选基因中的 DNA 序列变异。 这项辅助研究的数据将与核心 CARDIA 检查数据相结合，以实现以下目标： 一个。检查体重和成分、脂肪分布、客观测量的体力活动和特定遗传多态性对 20 岁有氧能力差异以及从青年期到中年 20 年期间与年龄相关的有氧能力下降的影响，按种族和性别进行分层。 b.纵向检查有氧能力对心血管疾病危险因素变化和 CVD 相关终点（例如高血压、代谢综合征、亚临床疾病 [例如冠状动脉钙化]）发生率的影响。这项研究的数据应该提供帮助我们更深入地了解心肺健康、身体成分和心血管疾病相关危险因素和终点之间的相互关系的信息，并可能为关于健身在心血管健康中的作用的更广泛的循证建议提供基础。