20 YEAR CHANGES IN FITNESS & CARDIOVASCULAR DISEASE RISK

20年健身变化

• 批准号: 7017724
• 负责人: Stephen Sidney
• 金额: $ 206.86万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7017724
• 关键词: African American; adipose tissue; adolescence (12-20); aerobic exercise; body composition; cardiovascular disorder; cardiovascular disorder risk; caucasian American; clinical research; coronary disorder; gender difference; genetic polymorphism; human middle age (35-64); human subject; hypertension; longitudinal human study; metabolic syndrome; noninsulin dependent diabetes mellitus; obesity; oxygen consumption; photon absorptiometry; physical fitness; racial /ethnic difference; young adult human (21-34)

DESCRIPTION (provided by applicant): Although an age-related decline in aerobic capacity is well documented, the impact of physical activity, body fat, and genetic variation on the rate of change is not well understood. In addition, little is known about how rate of change in aerobic capacity during early and middle adulthood affects the development of cardiovascular disease risk factors or the incidence of subclinical and clinical cardiovascular disease (CVD) related end-points. We propose to address these issues by conducting an ancillary study in conjunction with the Year 20 CARDIA (Coronary Artery Risk Development in Young Adults) examination, which is scheduled to take place beginning in June, 2005. We anticipate that approximately 3,650 (75%) of the surviving members of the initial cohort of African American and white men and women will return for the Year 20 exam, at which point they will be 38-50 years old. The overall goal of the proposed ancillary study is to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and sub-clinical CVD. To accomplish this goal, we propose to measure, on all Year 20 CARDIA participants: 1. Aerobic capacity, by means of a symptom-limited graded exercise treadmill test, using the same protocol as that used in CARDIA at the Year 0 and Year 7 exams; 2. Body composition and fat distribution, using a whole body dual energy x-ray absorptiometery (DEXA) scan; 3. Physical activity, using 7 days of accelerometer recordings; and 4. DNA sequence variants in selected candidate genes associated with cardiorespiratory fitness, components of the metabolic syndrome, and response to regular exercise, using stored DNA. Data from this ancillary study will be combined with core CARDIA examination data to address the following aims: a. Examination of the contribution of body mass and composition, fat distribution, objectively measured physical activity and specific genetic polymorphisms to the variance in Year 20 aerobic capacity and in age-related decline in aerobic capacity over a 20-year time period from young adulthood to mid-life, stratifying by race and gender. b. Longitudinal examination of the effect of aerobic capacity on changes in cardiovascular disease risk factors and on the incidence of CVD-related endpoints (e.g. hypertension, metabolic syndrome, subclinical disease [e.g. coronary artery calcium]). Data from this study should provide information that will help us more deeply understand the interrelationships of cardiorespiratory fitness, body composition, and CVD-related risk factors and endpoints, and may provide the basis for more extensive evidence-based recommendations on the role of fitness in cardiovascular health.

描述（由申请人提供）：尽管有效的有氧运动能力与年龄相关的下降尚未得到充分证明，但体育锻炼，体内脂肪和遗传变异对变化率的影响尚不清楚。此外，关于成年早期和中期有氧能力的变化率如何影响心血管疾病危险因素的发展或亚临床和临床心血管疾病（CVD）相关终点的发生率几乎没有什么了解。我们建议通过进行辅助研究以及20年级的CADCIA（年轻人的冠状动脉风险发展）检查来解决这些问题，该检查计划于2005年6月开始进行。我们预计，大约有3,650（75％）在非洲裔美国和白人和白人和白人女性和妇女最初的群体中，大约有3,650名（75％）的年份将返回20年，他们将返回20年。拟议的辅助研究的总体目标是了解身体健康，身体活动，体重和脂肪分布以及遗传因素及其对肥胖，代谢综合征和亚临床CVD的独立或互动影响之间的复杂，纵向关系。为了实现这一目标，我们建议全年20岁的Cardia参与者进行衡量： 1。通过症状有限的分级运动跑步机测试，使用与CADDIA在0年级和7年级考试中使用的方案相同的方案；有氧运动能力； 2。使用全身双能X射线吸收仪（DEXA）扫描的身体成分和脂肪分布； 3.体育活动，使用7天的加速度计记录；和 4。使用储存的DNA，与心肺适应性，代谢综合征的成分以及对常规运动的反应相关的选定候选基因中的DNA序列变体。 这项辅助研究的数据将与Core Cardia检查数据相结合，以解决以下目的： 一个。检查体重和成分的贡献，脂肪分布，客观测量的体育活动以及特定的遗传多态性对20年有氧运动能力的差异以及与年龄相关的有氧运动能力下降的20岁时，从年轻成年到中年，从事种族和性别的分层。 b。纵向检查有氧能力对心血管疾病危险因素变化的影响以及与CVD相关终点的发生率（例如高血压，代谢综合征，亚临床疾病[例如冠状动脉钙]）。这项研究的数据应提供信息，以帮助我们更深入地了解心肺健康，身体组成和与CVD相关的危险因素和终点的相互关系，并可能为更广泛的循证建议提供有关健身在心血管健康中的作用的基础。