Methamphetamine Abuse: Natural History, Treatment Effect

A/M的使用越来越多，其使用的后果仍在继续 引起社会和政府的关注， 提高公众对改进拦截、预防和 和治疗战略，优先考虑研究工作， 这些战略。拟议继续进行的工作将进一步研究 接受治疗和未接受治疗的A/M用户的不同样本，以提供经验基础 以改进目前正在制定的预防和治疗战略。 继续将通过管理后续自然 历史访谈（NIH）对当前研究的400个样本进行随机抽样 1995-97年接受A/M治疗的个人， 洛杉矶县的门诊和住院项目。继续 我将扩大研究范围，采访（使用相同的NHI）用户样本 为了更好地了解未接受治疗的人， A/M使用过程和进入治疗的障碍。 将讨论两个主要目标：（1）评估AIM的长期使用模式 并确定A/M使用的长期后果，包括有条件的 人口统计学、背景和健康特征的影响， A/M使用史与其他物质使用、艾滋病毒/艾滋病风险的关系 行为，犯罪行为。A/M使用历史和相关 将比较处理组和未处理组之间的特征。（二） 检查长期治疗结果（包括 种族、性别、模态和其他用户特征）和 A/M用户的治疗利用率。动机、成瘾严重程度和其他 限制从未接受过治疗的样本接受治疗的障碍也将被 介绍了多变量分析，包括重复的广义模型 测量，生存分析，逻辑回归，结构方程模型， 和增长模型，以及人种学方法，将用于解决 这些目标。 从拟议的延续中获得的新数据将允许分析更长时间的A/M使用情况 长期治疗结果的历史和评估（尚未研究 AIM用户）。研究结果将有助于改善治疗推广战略， 参与、服务交付和保留，并设计风险降低 在治疗系统之外。

DESCRIPTION: The increasing use of A/M and the consequences of its use continue to generate social and governmental concern, which has been manifested in increased public attention and initiatives to improve interdiction, prevention, and treatment strategies, with a priority placed on research efforts to inform these strategies. The proposed continuation will conduct further research on a diverse sample of treated and untreated A/M users to provide an empirical basis for the improvement of prevention and treatment strategies now being developed. The continuation will extend the research by administering a follow-up Natural History Interview (NIH) to the current study's sample of 400 randomly sampled individuals admitted to treatment for A/M use in 1995-97 to publicly funded outpatient and residential programs in Los Angeles County. The continuation will expand the research to interview (using the same NHI) a sample of users who have never been in treatment in order to better understand the untreated course of A/M use and barriers to treatment entry. Two broad primary aims will be addressed: (1) Assess AIM use patterns over time and determine the long-term consequences of A/M use, including the conditional impact of demographic, background, and health characteristics, and the relationships of A/M use histories to other substance use, HIV/AIDS risk behaviors, and criminal behaviors. A/M use histories and related characteristics will be compared between the treated and untreated groups. (2) Examine long-term treatment outcomes (including differential effects for ethnicity, gender, modality, and other user characteristics) and patterns of treatment utilization for A/M users. Motivation, addiction severity, and other barriers limiting treatment access for the never-treated sample will also be described. Multivariate analyses including generalized models for repeated measures, survival analysis, logistic regression, structural equation modeling, and growth modeling, as well as ethnographic methods, will be used to address these aims. New data from the proposed continuation will allow analysis of longer A/M use histories and assessment of long-term treatment outcomes (not yet studied for AIM users). Findings will serve to improve strategies for treatment outreach, engagement, service delivery, and retention, and to design risk reduction programs exterior to the treatment system.