Methamphetamine Abuse: Natural History, Treatment Effect

描述：越来越多地使用A/M及其后果仍在继续 引起社会和政府的关注，这已经体现在 提高公众的关注度和主动行动，以改善拦截、预防、 和治疗战略，优先考虑研究工作，以告知 这些策略。拟议的延续将对一个 已处理和未处理的A/M用户的不同样本提供经验基础 用于改进目前正在制定的预防和治疗战略。 继续研究将通过执行后续的自然 历史访谈(NIH)对当前研究的400个样本进行随机抽样 1995-97年度因使用空调药物而获准接受治疗的人士 洛杉矶县的门诊和住宿计划。续集 将扩大研究以访问(使用相同的NHI)用户样本 他们从未接受过治疗，以便更好地了解未接受治疗的人 使用A/M的过程和进入治疗的障碍。 主要目标有两个：(1)评估随时间推移的AIM使用模式 并确定使用A/M的长期后果，包括有条件的 人口、背景和健康特征的影响，以及 A/M使用史与其他物质使用、HIV/AIDS风险的关系 行为，和犯罪行为。A/M使用历史及相关 治疗组和未治疗组之间的特征将进行比较。(2) 检查长期治疗结果(包括对 种族、性别、形态和其他用户特征)和模式 A/M用户的治疗利用率。动机、成瘾严重程度和其他 限制未经处理样本的处理途径的障碍也将是 描述。包含广义重复模型的多变量分析 度量、生存分析、Logistic回归、结构方程建模、 并将使用增长建模以及人种学方法来解决 这些目标。 拟议延续的新数据将有助于分析较长时间的A/M使用情况 长期治疗结果的病史和评估(尚未进行研究 目标用户)。研究结果将有助于改进外展治疗的战略， 参与、服务交付和保留，并设计降低风险 处理系统外部的程序。

DESCRIPTION: The increasing use of A/M and the consequences of its use continue to generate social and governmental concern, which has been manifested in increased public attention and initiatives to improve interdiction, prevention, and treatment strategies, with a priority placed on research efforts to inform these strategies. The proposed continuation will conduct further research on a diverse sample of treated and untreated A/M users to provide an empirical basis for the improvement of prevention and treatment strategies now being developed. The continuation will extend the research by administering a follow-up Natural History Interview (NIH) to the current study's sample of 400 randomly sampled individuals admitted to treatment for A/M use in 1995-97 to publicly funded outpatient and residential programs in Los Angeles County. The continuation will expand the research to interview (using the same NHI) a sample of users who have never been in treatment in order to better understand the untreated course of A/M use and barriers to treatment entry. Two broad primary aims will be addressed: (1) Assess AIM use patterns over time and determine the long-term consequences of A/M use, including the conditional impact of demographic, background, and health characteristics, and the relationships of A/M use histories to other substance use, HIV/AIDS risk behaviors, and criminal behaviors. A/M use histories and related characteristics will be compared between the treated and untreated groups. (2) Examine long-term treatment outcomes (including differential effects for ethnicity, gender, modality, and other user characteristics) and patterns of treatment utilization for A/M users. Motivation, addiction severity, and other barriers limiting treatment access for the never-treated sample will also be described. Multivariate analyses including generalized models for repeated measures, survival analysis, logistic regression, structural equation modeling, and growth modeling, as well as ethnographic methods, will be used to address these aims. New data from the proposed continuation will allow analysis of longer A/M use histories and assessment of long-term treatment outcomes (not yet studied for AIM users). Findings will serve to improve strategies for treatment outreach, engagement, service delivery, and retention, and to design risk reduction programs exterior to the treatment system.