Early Determinants of Breast Cancer Risk

乳腺癌风险的早期决定因素

• 批准号: 6514994
• 负责人: MARY BETH TERRY
• 金额: $ 7.83万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6514994
• 关键词: age at pregnancy; breast neoplasms; cancer risk; clinical research; dopamine receptor; female; genetic polymorphism; handedness; human birth weight; human subject; leptin; mammography; neoplasm /cancer epidemiology; preeclampsia; tetrahydrofolates; twin /multiplet; women's health

DESCRIPTION (provided by applicant): Traditional risk factor epidemiology has contributed to many public health breakthroughs revealing notable associations such as cigarette smoking and lung cancer. Recently, however, it has been challenged to further development. Some have suggested its methods are too imprecise to disentangle more subtle associations. Others have called for new paradigm shifts that consider not only individual risk factors but also factors at other levels as small as genes and as large as community and society. Training in other approaches is crucial in facing these challenges. This career development award will enable me to combine my training in traditional cancer epidemiologic methods with complementary expertise in other areas. My goal is to become an independent cancer epidemiologist who tackles research questions using a life course perspective. Five areas of training are proposed: recruitment and retention in urban populations, molecular epidemiology, perinatal epidemiology, advanced statistical methods, and ethics. My training in these areas will be supervised by four mentors -- Ezra Susser, M.D., Dr.P.H., Geoffrey Howe, Ph.D., Ruby Senie, Ph.D., and Regina Santella, Ph.D. The training objectives are directly related to my proposed research, which focuses on early determinants of breast cancer risk. My research projects will contribute to the existing literature in two main ways: 1) By developing refined and novel approaches of studying the influence of early life factors such as birthweight and preeclampsia; and 2) By investigating how these factors interact with childhood and adolescent factors in determining breast cancer risk. Newly collected data will enhance three ongoing studies: The Metropolitan New York Registry of Breast Cancer Families, the New York site of the National Collaborative Perinatal Project (NCPP), and the Early Determinants of Adult Health (EDAH) cohort. Extending the framework with which to view adult epithelial tumors like breast cancer to include the in utero period will promote a more thorough investigation of various stages along the life course as well as a more thoughtful integration of cancer risk factors with other disease processes.

描述（由申请人提供）：传统的流行病学危险因素有