Early Determinants of Breast Cancer Risk

乳腺癌风险的早期决定因素

• 批准号: 6993656
• 负责人: MARY BETH TERRY
• 金额: $ 5.6万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993656
• 关键词: age at pregnancy; breast neoplasms; cancer risk; clinical research; dopamine receptor; female; genetic polymorphism; handedness; human birth weight; human subject; leptin; mammography; neoplasm /cancer epidemiology; preeclampsia; tetrahydrofolates; twin /multiplet; women' s health

DESCRIPTION (provided by applicant): Traditional risk factor epidemiology has contributed to many public health breakthroughs revealing notable associations such as cigarette smoking and lung cancer. Recently, however, it has been challenged to further development. Some have suggested its methods are too imprecise to disentangle more subtle associations. Others have called for new paradigm shifts that consider not only individual risk factors but also factors at other levels as small as genes and as large as community and society. Training in other approaches is crucial in facing these challenges. This career development award will enable me to combine my training in traditional cancer epidemiologic methods with complementary expertise in other areas. My goal is to become an independent cancer epidemiologist who tackles research questions using a life course perspective. Five areas of training are proposed: recruitment and retention in urban populations, molecular epidemiology, perinatal epidemiology, advanced statistical methods, and ethics. My training in these areas will be supervised by four mentors -- Ezra Susser, M.D., Dr.P.H., Geoffrey Howe, Ph.D., Ruby Senie, Ph.D., and Regina Santella, Ph.D. The training objectives are directly related to my proposed research, which focuses on early determinants of breast cancer risk. My research projects will contribute to the existing literature in two main ways: 1) By developing refined and novel approaches of studying the influence of early life factors such as birthweight and preeclampsia; and 2) By investigating how these factors interact with childhood and adolescent factors in determining breast cancer risk. Newly collected data will enhance three ongoing studies: The Metropolitan New York Registry of Breast Cancer Families, the New York site of the National Collaborative Perinatal Project (NCPP), and the Early Determinants of Adult Health (EDAH) cohort. Extending the framework with which to view adult epithelial tumors like breast cancer to include the in utero period will promote a more thorough investigation of various stages along the life course as well as a more thoughtful integration of cancer risk factors with other disease processes.

描述(申请人提供)：传统的危险因素流行病学有 对许多公共卫生突破做出了贡献，揭示了显著的关联 比如吸烟和肺癌。然而，最近，它一直在 面临进一步发展的挑战。一些人认为它的方法也是 解开更微妙的联系是不精确的。其他人则呼吁建立新的 不仅考虑个人风险因素，而且还考虑 其他水平的因素，小到基因，大到群落和 社会。在面对这些挑战时，其他方法的培训至关重要。 这个职业发展奖将使我能够将我在 传统的癌症流行病学方法与其他领域的专业知识互补 区域。我的目标是成为一名独立的癌症流行病学家 从生命历程的角度研究问题。五个培训领域 建议：在城市人口中招募和保留，分子 流行病学、围产期流行病学、高级统计方法和 伦理道德。我在这些方面的培训将由四位导师监督--以斯拉 Susser、M.D.、Dr.P.H.、Geoffrey Howe、Ph.D.、Ruby Senie、Ph.D.和Regina 桑特拉博士。 培训目标与我提出的研究直接相关， 重点研究乳腺癌风险的早期决定因素。我的研究项目 将以两种主要方式对现有文献作出贡献：1)通过开发 研究早期生活因素影响的改进和创新方法 例如出生体重和先兆子痫；以及2)通过研究这些因素如何 决定乳房的因素与儿童和青春期因素相互作用 癌症风险。新收集的数据将加强正在进行的三项研究： 纽约大都会乳腺癌家庭登记处，纽约网站 国家合作围产期项目(NCPP)和早期 成人健康的决定因素(Edah)队列。通过以下方式扩展框架 要查看成人上皮性肿瘤，如乳腺癌，应包括在 子宫时期将促进对各个阶段的更彻底的调查 以及更深思熟虑地整合癌症风险 与其他疾病过程有关的因素。

项目成果

Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study.

• DOI: 10.1289/ehp.1205921
• 发表时间: 2013-05
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: La Merrill M;Cirillo PM;Terry MB;Krigbaum NY;Flom JD;Cohn BA
• 通讯作者: Cohn BA

Prenatal and childhood environmental tobacco smoke exposure and age at menarche.

产前和儿童时期环境烟草烟雾暴露和初潮年龄。

• DOI: 10.1111/j.1365-3016.2010.01154.x
• 发表时间: 2010-11
• 期刊: Paediatric and perinatal epidemiology
• 影响因子: 2.8
• 作者: Ferris JS;Flom JD;Tehranifar P;Mayne ST;Terry MB
• 通讯作者: Terry MB

Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort.

• DOI: 10.1158/1055-9965.epi-11-0553
• 发表时间: 2011-12
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Flom JD;Ferris JS;Liao Y;Tehranifar P;Richards CB;Cho YH;Gonzalez K;Santella RM;Terry MB
• 通讯作者: Terry MB

The role of birth cohorts in studies of adult health: the New York women's birth cohort.

• DOI: 10.1111/j.1365-3016.2009.01061.x
• 发表时间: 2009-09
• 期刊: Paediatric and perinatal epidemiology
• 影响因子: 2.8
• 作者: Terry MB;Flom J;Tehranifar P;Susser E
• 通讯作者: Susser E

Early life socioeconomic environment and mammographic breast density.

早期生活的社会经济环境和乳房X光检查乳房密度。

• DOI: 10.1186/s12885-016-3010-x
• 发表时间: 2017
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Tehranifar,Parisa;Cohn,BarbaraA;Flom,JulieD;Protacio,Angeline;Cirillo,Piera;Lumey,LH;Michels,KarinB;Terry,MaryBeth
• 通讯作者: Terry,MaryBeth