Early Determinants of Breast Cancer Risk

乳腺癌风险的早期决定因素

• 批准号: 6835209
• 负责人: MARY BETH TERRY
• 金额: $ 13.43万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6835209
• 关键词: age at pregnancy; breast neoplasms; cancer risk; clinical research; dopamine receptor; female; genetic polymorphism; handedness; human birth weight; human subject; leptin; mammography; neoplasm /cancer epidemiology; preeclampsia; tetrahydrofolates; twin /multiplet; women' s health

DESCRIPTION (provided by applicant): Traditional risk factor epidemiology has contributed to many public health breakthroughs revealing notable associations such as cigarette smoking and lung cancer. Recently, however, it has been challenged to further development. Some have suggested its methods are too imprecise to disentangle more subtle associations. Others have called for new paradigm shifts that consider not only individual risk factors but also factors at other levels as small as genes and as large as community and society. Training in other approaches is crucial in facing these challenges. This career development award will enable me to combine my training in traditional cancer epidemiologic methods with complementary expertise in other areas. My goal is to become an independent cancer epidemiologist who tackles research questions using a life course perspective. Five areas of training are proposed: recruitment and retention in urban populations, molecular epidemiology, perinatal epidemiology, advanced statistical methods, and ethics. My training in these areas will be supervised by four mentors -- Ezra Susser, M.D., Dr.P.H., Geoffrey Howe, Ph.D., Ruby Senie, Ph.D., and Regina Santella, Ph.D. The training objectives are directly related to my proposed research, which focuses on early determinants of breast cancer risk. My research projects will contribute to the existing literature in two main ways: 1) By developing refined and novel approaches of studying the influence of early life factors such as birthweight and preeclampsia; and 2) By investigating how these factors interact with childhood and adolescent factors in determining breast cancer risk. Newly collected data will enhance three ongoing studies: The Metropolitan New York Registry of Breast Cancer Families, the New York site of the National Collaborative Perinatal Project (NCPP), and the Early Determinants of Adult Health (EDAH) cohort. Extending the framework with which to view adult epithelial tumors like breast cancer to include the in utero period will promote a more thorough investigation of various stages along the life course as well as a more thoughtful integration of cancer risk factors with other disease processes.

描述（由申请人提供）：传统的风险因素流行病学 促成了许多公共卫生突破，揭示了显着的关联 例如吸烟和肺癌。 然而，最近， 挑战进一步发展。 有些人认为它的方法也 不精确，以解开更微妙的联系。 其他人呼吁新的 范式转变不仅考虑个人风险因素， 其他层面的因素，小到基因，大到社区， 社会 其他方法的培训对于应对这些挑战至关重要。 这个职业发展奖将使我能够联合收割机结合我的培训， 传统的癌症流行病学方法与其他领域的互补专业知识 地区 我的目标是成为一名独立的癌症流行病学家， 从生命历程的角度研究问题。 五个培训领域 在城市人口中的招募和保留， 流行病学，围产期流行病学，先进的统计方法， 伦理 我在这些领域的训练将由四位导师指导以斯拉 Susser，医学博士，博士，杰弗里·豪博士，Ruby Senie博士，和里贾纳 Santella博士 培训目标与我提出的研究直接相关， 关注乳腺癌风险的早期决定因素。 我的研究项目 将有助于现有的文献在两个主要方面：1）通过发展 研究早期生活因素影响的精细和新颖的方法 如出生体重和先兆子痫;和2）通过调查这些 在决定乳腺癌的发病率方面， 癌症风险。 新收集的数据将加强三项正在进行的研究： 大都会纽约乳腺癌家庭登记处，纽约网站， 国家围产期合作项目（NCPP）和早期 成人健康决定因素（EDAH）队列。 扩展框架， 将乳腺癌等成人上皮性肿瘤包括在 子宫期将促进对各个阶段的更彻底的调查 沿着生命历程以及更周到的癌症风险整合 与其他疾病的关系。