Design of a VHEE Radiotherapy Machine: A Potential New Paradigm in Cancer Treatment

VHEE 放射治疗机的设计：癌症治疗的潜在新范式

• 批准号: 1961878
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1961878
• 关键词: Design; VHEE; Radiotherapy; Machine; Potential

There is the opportunity for a Ph.D. student to develop a high gradient linac and associated RF, operating at 200 - 250 MV, suitable for a VHEE radiotherapy machine. This research will allow for a potential new paradigm in cancer treatment. The work will capitalise on more than two decades of research conducted for CLIC (Compact Linear Collider) at CERN. With suitable adaptation, a full radiotherapy electron machine will be investigated, capable of delivering a high dose at a rapid rate -and hence able to take advantage of the latest advances in ultrahigh dose -rate "FLASH" radiotherapy. Each accelerating structure will operate at ~ 100 MV/m with the capability of delivering 10s Gy in a highly conformal manner. Part of the Ph.D. will also entail the practicality of steering multiple linacs to the treatment area -and hence investigate "freezing" patient motion. This will entail a collaboration with the University of Manchester, Daresbury Lab., Elekta and CERN. There will be RF, beam dynamics, vacuum science, and mechanical engineering aspects to this project. The practicalities of realising a VHEE radiotherapy machine within a realistic timeframe will be explored. The project has analytical, simulation, and experimental aspects to the research. The direction of the research will be decided according to the interest and aptitude of the student.

有机会获得博士学位。学生开发一个高梯度直线加速器和相关的射频，在200 - 250 MV，适用于VHEE放射治疗机。这项研究将为癌症治疗提供一种潜在的新模式。这项工作将利用CERN为CLIC（紧凑型线性对撞机）进行的二十多年的研究。 通过适当的调整，将研究一种完整的放射治疗电子机器，它能够以快速的速度提供高剂量，因此能够利用最新的高剂量率“FLASH”放射治疗的优势。每个加速结构将以~ 100 MV/m的速度运行，并具有以高度保形的方式提供10 s戈伊的能力。博士学位的一部分还需要将多个直线加速器转向治疗区域的实用性，从而研究“冻结”患者运动。这将需要与曼彻斯特大学达雷斯伯里实验室合作，Elekta和CERN。 将有射频，光束动力学，真空科学和机械工程方面的这个项目。将探索在现实的时间范围内实现VHEE放射治疗机的实用性。该项目有分析，模拟和实验方面的研究。研究的方向将根据学生的兴趣和能力来决定。