Endocannabinoid-TRP interactions in midbrain analgesic pathways

中脑镇痛通路中内源性大麻素-TRP 的相互作用

• 批准号: nhmrc : 1003097
• 负责人: Dr Christopher Vaughan
• 金额: $ 39.13万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endocannabinoid-trp-interactions-analgesic-pathways/108894
• 关键词: Endocannabinoid; TRP; interactions; midbrain; analgesic

Current pharmacotherapies for chronic pain are often ineffective. The active ingredient of the plant Cannabis sativa, THC, and a number of synthetic cannabinoids have efficacy in these pain states, however, they also produce a spectrum of adverse side-effects. This project will use cellular and behavioural techniques to examine how this cannabinoid system modulates intrinsic pain systems within the midbrain in order provide leads for novel analgesic pharmacotherapies with enhanced efficacy.

目前慢性疼痛的药物治疗往往是无效的。植物大麻的活性成分，四氢大麻酚和一些合成大麻素对这些疼痛状态有效，然而，它们也会产生一系列不良副作用。该项目将使用细胞和行为技术来研究这种大麻素系统如何调节中脑内的内在疼痛系统，以便为增强疗效的新型镇痛药物治疗提供线索。