Molecular and Cellular Basis for the Analgesic Properties of N-Arachidonyl amino acids

N-花生四烯基氨基酸镇痛特性的分子和细胞基础

• 批准号: nhmrc : 402564
• 负责人: Dr Christopher Vaughan
• 金额: $ 33.94万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-cellular-basis-amino-acids/82380
• 关键词: Molecular; Cellular; Basis; Analgesic; Properties

Chronic pain affects 20% of the population of Australia, but current treatments for chronic pain are often problematic. A recently described class of compounds, the arachidonyl amino acids, show particular promise as analgesic agents, but at present there is very little understanding of how these compounds mediate their analgesic effects. In this project we will apply a variety of molecular, cellular and behavioural approaches to understand how the arachidonyl amino acids provide pain relief.

慢性疼痛影响着澳大利亚20%的人口，但目前治疗慢性疼痛的方法往往存在问题。最近描述的一类化合物，花生四烯基氨基酸，显示出作为止痛剂的特殊前景，但目前人们对这些化合物如何介导其镇痛作用知之甚少。在这个项目中，我们将应用各种分子、细胞和行为方法来了解花生四烯基氨基酸如何起到缓解疼痛的作用。