Molecular targets of amino acid/neurotransmitter conjugates of fatty acids

氨基酸/脂肪酸神经递质缀合物的分子靶点

• 批准号: nhmrc : 1002680
• 负责人: Dr Christopher Vaughan
• 金额: $ 56.44万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-targets-amino-fatty-acids/108848
• 关键词: Molecular; targets; amino; acid; neurotransmitter

This project investigates endogenous chemicals that affect cells important for detecting and responding to pain. We aim to discover how these compounds affect proteins important for nerve cell function, particularly proteins that have a prominent role in detecting and transmitting painful events. The compounds we examine are not themselves likely to be drugs, but future therapies may involve manipulating the levels of these chemicals in the body, or using drugs that mimic the activity of these compounds.

该项目研究影响对检测和响应疼痛重要的细胞的内源性化学物质。我们的目标是发现这些化合物如何影响对神经细胞功能至关重要的蛋白质，特别是在检测和传递疼痛事件中起重要作用的蛋白质。我们研究的化合物本身不太可能是药物，但未来的治疗方法可能涉及操纵这些化学物质在体内的水平，或使用模拟这些化合物活性的药物。