Endometrial receptivity for embryo implantation: Proprotein convertase 6 and plasma membrane remodeling

胚胎植入的子宫内膜容受性：前蛋白转化酶 6 和质膜重塑

• 批准号: nhmrc : 1044182
• 负责人: Ms Sarah Paule
• 金额: $ 42.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endometrial-receptivity-embryo-membrane-remodeling/111637
• 关键词: Endometrial; receptivity; embryo; implantation; Proprotein

Implantation of an embryo into the uterus is a key step in establishing pregnancy; it requires a receptive uterus (fertile soil) and a healthy embryo (seed). Implantation failure causes pregnancy loss and infertility, and is also a major limiting factor in IVF. We have established that proprotein convertase 6 (PC6) is a master regulator of uterine receptivity for implantation. We will investigate how PC6 works in a woman’s uterus, and how we can use this knowledge to improve implantation in IVF.

将胚胎植入子宫是建立妊娠的关键步骤;它需要一个可接受的子宫（肥沃的土壤）和一个健康的胚胎（种子）。着床失败导致妊娠丢失和不孕，也是IVF的主要限制因素。我们已经确定，前蛋白转化酶6（PC6）是一个主调节子宫容受性植入。我们将研究PC6如何在女性子宫中工作，以及我们如何利用这些知识来改善IVF中的植入。