CORE--EXPOSURE ANALYSIS AND HEALTH EFFECTS

暴露分析和健康影响的研究核心是 旨在提供开发和利用的专业知识 科学和临床方法，以表征暴露和 环境污染物对健康的影响。这个核心已经被重新命名了， 自上一个审查周期以来，部分重组并扩大了范围。这个 更名反映了将工作范围扩大到包括临床研究 除了环境流行病学，以及放置一个 更加重视针对确定暴露的生物标志物的研究。 纳入来自旧接触的流行病学方法活动 建模和流行病学研究实验室成为新的统计支撑 设施核心实验室，建立一个照射和剂量测定实验室 核心实验室和开发新的临床核心设施的结果是 在部分重组中。这一核心的具体目标既代表了 与前一个审查周期相比的更改和修改。所宣布的目标 包括：1)建立暴露和诊断模型 用药代动力学方法估算靶标所受毒剂的剂量 人口、个人或器官；2)开发和使用分析技术 它可以测量无机/无机化学物种和/或生物标志物 在受控和现场情况下暴露；3)设计和实施人类 受控和实地研究中的毒物暴露-反应研究； 4)设计和开展关于环境暴露的流行病学研究 对健康的影响；5)开展生理和心理的临床研究 暴露于环境应激源的后果的预测因子。这些 重新制定的对象反映了这一核心计划，将其工作扩展到 野外使用的暴露生物标志物的研制与验证 研究(环境流行病学和人群暴露评估)和 受控实验室/环境人体研究。这些新目标还包括 突出核心计划，制定受控人体暴露计划 研究，其中敏感和正常的受试者将暴露在不同的水平 单一化合物和复杂混合物在环境室内研究中的应用 结果评估包括：暴露的生物标记物，影响的生物标记物， 生理效应和心理或心理物理效应。

The Research Core on Exposure Analysis and Health Effects is directed toward providing expertise in the development and utilization of scientific and clinical approaches to the characterization of exposures and health effects of environmental contaminants. This core has been renamed, partially reorganized and broaden in scope since the last review cycle. The name change reflects expanding the scope of work to include clinical studies in addition to environmental epidemiology, as well as the placement of a greater emphasis on research directed at identifying biomarkers of exposure. Incorporation of epidemiologic methods activities from the old Exposure Modeling and Epidemiologic Research Laboratory into a new Statistical Support Facility Core Laboratory, establishment of a Exposure and Dosimetry Laboratory Core Laboratory and development of a new Clinical Core Facility has resulted in the partial reorganization. The specific goals of this core represent both changes and modifications from the previous review cycle. The stated goals include: 1) developing mechanistic and diagnostic models of exposure and pharmacokinetics to estimate dose of a toxic agent received by a target population, individual or organ; 2) develop and employ analytical techniques which can measure inorganic/inorganic chemical species and/or biologic markers of exposure in controlled and field situations; 3) design and conduct human exposure-response studies of toxic agents in controlled and field studies; 4) design and conduct epidemiologic research on environmental exposures and health effects; 5) develop clinical studies of physiological and psychological predictors of outcomes from exposures to environmental stressors. These reformulated objects reflect this cores plans to expand its work into the development and validations of biological markers of exposure for use in field studies (environmental epidemiologic and population exposure assessment) and controlled laboratory/environmental human studies. These new objectives also highlight the cores plans to develop a program of controlled human exposures studies, where sensitive and normal subjects will be exposed to varying levels of single compounds and complex mixtures in environmental chamber studies with outcome assessments to include: biomarkers of exposure, biomarkers of effect, physiological effects and psychological or psychophysical effects.