EXPOSURE ASSESSMENT AND INTERVENTION

描述(由申请人提供) 暴露评估和干预项目将提供量化的 儿童对神经毒物身体负荷的接触情况 神经紊乱和缺陷。调查人员的假设是： 1)这些孩子的独特行为导致他们高度暴露在 在其个人和居住环境中发现的神经毒物，以及2) 选定的干预措施可导致测量到的 神经学受损的儿童。每名志愿儿童将从 吃了与此相关的社区组成员的家庭 中心的申请。此次评选将与以下机构密切合作 临床科学项目。目标是获得分布的 这些神经病患者的个人和微环境暴露 儿童对神经毒物；包括特定的重金属，挥发性 有机物质和杀虫剂，存在并在当地有来源 儿童的环境、居住和个人环境。这些结果 将通过收集暴露测量数据来分析每个儿童随时间的变化 在两个不同的时间。在干预之前和之后各一次， 调查人员将根据时间尺度评估接触情况， 疾病终点的表达，并检查暴露的减少 在完成干预和家庭培训后发生。一次干预 将适用于社区团体和家庭，它们也应该 对普通大众有价值的。除了物理和化学之外 对其环境和身体内暴露的测量 流体，他们将记录这些孩子的行为。这个 调查人员将使用通过录像开发的创新方法 并通过这一应用中的核心研究进行了补充。在整个课程中 该项目将提供数据，可用于增强 基础生物科学项目使用的神经毒物。

DESCRIPTION (provided by applicant) The exposure assessment and intervention project will provide quantitative data on the contact with body burden of neurotoxicants within children having neurological disorders and deficits. The investigators' hypotheses are that: 1) the unique behaviors of these children lead to high exposure to neurotoxicants found in their personal and residential environment, and 2) selected interventions can lead to reductions in exposure measured for neurologically impaired children. Each volunteer child will be selected from families that ate members ofthe community groups associated with this Center's application. The selection will be done in close collaboration with the Clinical Sciences Projects. The goal is to obtain the distribution of personal and micro-environmental exposure of these neurologically impaired children to neurotoxicants; including specific heavy metals, volatile organics, and pesticides that are present and have sources in the local ambient and residential and personal environments of the child. These results will be analyzed over time for each child by collecting exposure measurements at two different times. Once before and once after an intervention, the investigators will assess exposure over time scales coincident with the expression of disease endpoints, and examine reductions in exposure that can occur after completing the intervention and family training. An intervention will apply to the community groups and families, and they should also be valuable to the general public. In addition to the physical and chemical measurements of exposure within their environments and within their bodily fluids, they will be documenting the behavior of these children. The investigators will be using the innovative approaches developed by videotaping and augmented by the core research in this application. Throughout the course of the study, the project will provide data that can be used to augment the neurotoxicants employed by the Basic Biological Sciences Projects.