Core--Environmental carcinogenesis

高频率/低频率基因的研究及其作用机制 影响癌基因和抑癌基因的突变率是一个令人兴奋的 调查领域。研究核心2的目标是促进和支持 研究复杂的基因/环境相互作用， 癌症风险，特别是因为它涉及影响 肿瘤抑制基因突变的异常率。这将由一个 跨学科研究的三种方法。一是支持 肿瘤发生的分子和遗传机制的基础研究 实验室调查员;第二个将在基础领域 流行病学;第三个将是分子和 流行病学研究。具体而言，将进行研究， 致癌物作用机制，致突变和表观遗传机制， 多阶段致癌、鉴定、克隆和功能 癌症易感基因和癌基因的表征，暴露 癌症危险因素的流行病学研究、遗传和 癌症风险的环境调节剂和癌症预防研究。

The study of high frequency/low penetrance genes and how they affect mutation rates of oncogenes and tumor suppressor genes is an exciting area of investigation. The goal of Research Core 2 is to foster and support research into the complex gene/environment interactions that define individual cancer risk, particularly as it relates to genetic polymorphisms that affect penetrance of tumor suppressor gene mutations. This will be accomplished by a three pronged approach to interdisciplinary research. The first is to support basic studies of molecular and genetic mechanisms of carcinogenesis among the laboratory-based investigators; the second will be in the area of basic epidemiology; and the third will be the interface of molecular and epidemiologic studies. Specifically, studies will be conducted to evaluate mechanisms of carcinogen action, mutagenic and epigenetic mechanisms in multistage carcinogenesis, identification, cloning, and functional characterization of cancer susceptibility genes and oncogenes, exposure assessment, epidemiological studies of cancer risk factors, genetic and environmental modifiers of cancer risk, and cancer prevention studies.