Physiologic Characterization of Occupational Asthma

职业性哮喘的生理特征

• 批准号: 6471660
• 负责人: SUSAN R SAMA
• 金额: $ 8.1万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6471660
• 关键词: asthma; biomarker; breath composition; breath tests; bronchodilators; clinical research; early diagnosis; environmental air flow; human subject; interview; occupational hazard; occupational health /safety; occupational stressor; pathologic process; pollution related respiratory disorder; quality of life; questionnaires; respiratory disorder epidemiology; spirometry

DESCRIPTION: This Special Emphasis Research Award will provide an opportunity for a young occupational epidemiologist to be released from routine field study responsibilities to develop her own cutting edge research on molecular biomarkers in exhaled breath and to gain training and experience in the application of modern longitudinal biostatistical methods in occupational respiratory epidemiology. This project will take maximum advantage of large and well-funded ongoing community-based studies of occupational asthma and of the depth and breadth of Harvard?s academic environment. Occupational asthma (OA) accounts for 5 percent to 36 percent of asthma in adults and occupational exposure are major contributors to morbidity among adult asthmatics. Early detection and intervention are essential for primary as well as secondary prevention of OA. Unfortunately, the physiologic manifestations of OA are poorly understood and easily measured noninvasive biomarkers of OA are sorely needed. Current methods based on peak expiratory flow (PEF) diaries are effort dependent and the quality of the efforts and records cannot be controlled. This project will address these pressing needs by illuminating the relationship between the four work-related asthmatic airflow patterns (WRAAP) described by Sherwood Burge for PEF diaries and WRAAP observed using portable electronic spirometers, and a more sophisticated physiologic and noninvasive biomarker of airway inflammation. This study will lay the foundation for application of these new methods not only in future occupational epidemiologic studies, but also in industrial screening and outpatient clinics. Thus, this study will light a path toward improved detection and prevention of OA.

描述：该特别重点研究奖将提供一个机会 让年轻的职业流行病学家从日常的现场研究中解脱出来 负责发展自己的分子前沿研究 呼出气中的生物标志物，并获得相关方面的培训和经验 现代纵向生物统计方法在职业中的应用 呼吸道流行病学。该项目将最大限度地利用大型和 资金充足、正在进行的以社区为基础的职业性哮喘研究 哈佛大学学术环境的深度和广度。 职业性哮喘 (OA) 占全球哮喘的 5% 至 36% 成人和职业暴露是导致儿童发病的主要原因 成人哮喘患者。早期发现和干预对于初级保健至关重要 以及OA的二级预防。不幸的是，生理 人们对 OA 的表现知之甚少，但也很容易通过非侵入性方法进行测量 迫切需要 OA 的生物标志物。当前基于呼气峰的方法 流量（PEF）日记取决于努力程度，并且努力的质量和 记录无法控制。该项目将通过以下方式解决这些紧迫的需求 阐明四种与工作相关的哮喘气流之间的关系 Sherwood Burge 为 PEF 日记描述的模式 (WRAAP) 和观察到的 WRAAP 使用便携式电子肺活量计以及更复杂的生理和 气道炎症的非侵入性生物标志物。这项研究将奠定 为这些新方法的应用奠定了基础，不仅在未来的职业中 流行病学研究，还用于工业筛查和门诊诊所。 因此，这项研究将为改进检测和预防指明道路 办公自动化。