Physiologic Characterization of Occupational Asthma

职业性哮喘的生理特征

• 批准号: 6661888
• 负责人: SUSAN R SAMA
• 金额: $ 8.1万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6661888
• 关键词: asthma; biomarker; breath composition; breath tests; bronchodilators; clinical research; early diagnosis; environmental air flow; human subject; interview; occupational hazard; occupational health /safety; occupational stressor; pathologic process; pollution related respiratory disorder; quality of life; questionnaires; respiratory disorder epidemiology; spirometry

DESCRIPTION: This Special Emphasis Research Award will provide an opportunity for a young occupational epidemiologist to be released from routine field study responsibilities to develop her own cutting edge research on molecular biomarkers in exhaled breath and to gain training and experience in the application of modern longitudinal biostatistical methods in occupational respiratory epidemiology. This project will take maximum advantage of large and well-funded ongoing community-based studies of occupational asthma and of the depth and breadth of Harvard?s academic environment. Occupational asthma (OA) accounts for 5 percent to 36 percent of asthma in adults and occupational exposure are major contributors to morbidity among adult asthmatics. Early detection and intervention are essential for primary as well as secondary prevention of OA. Unfortunately, the physiologic manifestations of OA are poorly understood and easily measured noninvasive biomarkers of OA are sorely needed. Current methods based on peak expiratory flow (PEF) diaries are effort dependent and the quality of the efforts and records cannot be controlled. This project will address these pressing needs by illuminating the relationship between the four work-related asthmatic airflow patterns (WRAAP) described by Sherwood Burge for PEF diaries and WRAAP observed using portable electronic spirometers, and a more sophisticated physiologic and noninvasive biomarker of airway inflammation. This study will lay the foundation for application of these new methods not only in future occupational epidemiologic studies, but also in industrial screening and outpatient clinics. Thus, this study will light a path toward improved detection and prevention of OA.

描述：这个特别重视研究奖将为机会提供机会 对于年轻的职业流行病学家，可以从常规现场研究中释放 开发自己的尖端研究的责任研究 呼气中的生物标志物，并获得培训和经验 现代纵向生物统计学方法在职业中的应用 呼吸流行病学。该项目将最大程度地利用大的优势和 资金充足的基于社区的职业哮喘和 哈佛大学的学术环境的深度和广度。 职业哮喘（OA）占哮喘的5％至36％ 成人和职业接触是导致发病率的主要因素 成人哮喘患者。早期检测和干预对于初级是必不可少的 以及对OA的次要预防。不幸的是，生理学 OA的表现知之甚少，很容易测量无创的 非常需要OA的生物标志物。基于峰值呼气的当前方法 流量（PEF）日记取决于努力和努力的质量和 记录无法控制。该项目将通过 照亮四个与工作有关的哮喘气流之间的关系 Sherwood Burge描述的图案（WRAAP）为PEF日记和WRAAP观察到了 使用便携式电子肺活量计以及更复杂的生理学和 气道炎症的无创生物标志物。这项研究将为 这些新方法的应用基础不仅在未来的职业中 流行病学研究，以及工业筛查和门诊诊所。 因此，这项研究将为改善检测和预防的途径介绍 OA。