ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA

阻塞性睡眠呼吸暂停中舌肌的激活

• 批准号: 6490759
• 负责人: DOMINIQUE M DURAND
• 金额: $ 15.3万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6490759
• 关键词: bioengineering /biomedical engineering; decerebration; dogs; electrostimulus; fiber optics; hypoglossal nerve; medical implant science; neuroimaging; neuromuscular stimulator; respiratory airflow disorder; sleep apnea; technology /technique development; tongue

DESCRIPTION:(adapted from applicant's abstract) This project aims to develop an experimental therapy for obstructive sleep apnea (OSA) using electrical stimulation of the hypoglossal nerve. The PI proposes to use a multi-channel stimulation technique for selective activation of portions of the hypoglossal nerve to activate individual tongue muscles selectively. Such stimulation might increase control over the tongue muscles and improve efficiency for electrical stimulation to remove pharyngeal obstruction. There are 3 aims to be tested in dogs. Aim 1 will determine the maximum muscle selectivity that can be obtained with a multi-contact electrode on the hypoglossal nerve. Aim 2 will evaluate the mechanical dilation of the airways due to selective stimulation. Aim 3 will determine the optimum electrode geometries and stimulation paradigms for airway dilation in chronic dogs. It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA.

描述：（改编自申请人摘要）