Microanalytical System for Indoor VOC Monitoring

室内 VOC 监测微量分析系统

• 批准号: 6475355
• 负责人: EDWARD T ZELLERS
• 金额: $ 29.6万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6475355
• 关键词: air pollution; air sampling /monitoring; biomedical equipment development; evaluation /testing; gas chromatography; high throughput technology; monitoring device; occupational health /safety; organic chemicals; sample collection; vapor; work site

DESCRIPTION: Continued research on the development and implementation of a high-performance micro analytical system capable of on-site speciated analysis of volatile and semi-volatile organic compounds (VOCs and SVOCs) encountered as complex mixtures at low-/sub-part-per-billion concentrations in non-industrial indoor working environments is proposed. Application to other occupational health monitoring needs will also be addressed. During the first finding cycle of this project, we succeeded in producing and characterizing the performance of a notebook-computer-sized fieldable instrument that employs preconcentration, thermal desorption, high-speed tunable separation, and microsensor-array detection. Detection limits ranging from 0.06 - 17 ppb have been achieved for the components of mixtures of >30 VOCs/SVOCs spanning a 10,000-fold range of vapor pressures captured from l-L air samples. Response patterns combined with chromatographic retention times have been used for vapor identification. Analytical cycle times of < 10 min are possible. Meeting these goals has also led to advances in adsorbent-preconcentrator design, dual-column pressure/temperature-modulated separations using air as carrier gas, and vapor detection, recognition, and quantification with ultra-miniature arrays of polymer-coated surface-acoustic-wave (SAW) microsensors. Here, we propose to field test this first-generation instrument in office buildings and to explore its application for breath analysis and for industrial air monitoring where vapor concentrations tend to be higher. Development of a second-generation microanalytical system with the following refinements/additions is also proposed: a wireless interface to permit unattended operation; an on-board vapor generator for automatic field calibration and system diagnostics; use of an alternative sensor technology with greater sensitivity to reduce sample volumes and/or detection limits; addition of a focusing element to reduce inlet bandwidths and use of alternative separation strategies to improve chromatographic resolution/versatility and reduce analysis time; and implementation of Si-micromachined components to reduce size and power. Laboratory and field testing of this second-generation instrument will then be performed. This system represents a significant advancement over the current state-of-the-art in monitoring instrumentation for complex vapor mixtures, obviating the need for conventional sorbent-tube/GC-MS methods for routine indoor air (and other) monitoring. The versatility of this instrument will facilitate the assessment of exposure distributions and the implementation of rational intervention strategies related to indoor air quality and other occupational health problems.

说明：继续研究制定和执行一项 可现场进行形态分析高性能微量分析系统 挥发性和半挥发性有机化合物（VOC和SVOC）， 在非工业环境中低/低于十亿分之一浓度的复杂混合物 室内工作环境。适用于其他职业 卫生监测需求也将得到满足。在第一个寻找周期中 在这个项目中，我们成功地制作和表征了 一个笔记本电脑大小的野外仪器， 预浓缩，热解吸，高速可调分离，和 微传感器阵列检测检测限范围为0.06 - 17 ppb， 对于>30种VOC/SVOC的混合物组分， 从I-L空气样品捕获的10，000倍范围的蒸气压。响应 与色谱保留时间相结合的模式已被用于蒸汽 识别. < 10分钟的分析周期时间是可能的。满足这些 goals还导致了吸附器预浓缩器设计、双柱 使用空气作为载气和蒸汽的压力/温度调制分离 检测，识别和定量与超微型阵列， 聚合物涂层表面声波（SAW）微传感器。在此，我们建议 在办公楼中实地测试这款第一代仪器， 其用于呼吸分析和工业空气监测的应用， 蒸汽浓度趋于更高。开发第二代 具有以下改进/添加的微量分析系统也是 建议：一个无线接口，允许无人值守操作;一个板载 自动现场校准和系统诊断用蒸汽发生器.使用 具有更高灵敏度的替代传感器技术， 体积和/或检测限;增加聚焦元件以减少入口 带宽和使用替代分离策略， 色谱分辨率/多功能性，减少分析时间;以及 实施硅微机械部件以减小尺寸和功率。 第二代仪器的实验室和现场测试将在 执行。该系统代表了对当前系统的重大进步。 在用于复杂蒸汽混合物的监测仪器中， 避免了常规的吸附管/GC-MS方法， 室内空气（和其他）监测。该仪器的多功能性将 促进评估暴露分布和实施 室内空气质量等相关的合理干预策略 职业健康问题。