Microanalytical System for Indoor VOC Monitoring

室内 VOC 监测微量分析系统

• 批准号: 6624493
• 负责人: EDWARD T ZELLERS
• 金额: $ 24.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6624493
• 关键词: air pollution; air sampling /monitoring; biomedical equipment development; evaluation /testing; gas chromatography; high throughput technology; monitoring device; occupational health /safety; organic chemicals; sample collection; vapor; work site

DESCRIPTION: Continued research on the development and implementation of a high-performance micro analytical system capable of on-site speciated analysis of volatile and semi-volatile organic compounds (VOCs and SVOCs) encountered as complex mixtures at low-/sub-part-per-billion concentrations in non-industrial indoor working environments is proposed. Application to other occupational health monitoring needs will also be addressed. During the first finding cycle of this project, we succeeded in producing and characterizing the performance of a notebook-computer-sized fieldable instrument that employs preconcentration, thermal desorption, high-speed tunable separation, and microsensor-array detection. Detection limits ranging from 0.06 - 17 ppb have been achieved for the components of mixtures of >30 VOCs/SVOCs spanning a 10,000-fold range of vapor pressures captured from l-L air samples. Response patterns combined with chromatographic retention times have been used for vapor identification. Analytical cycle times of < 10 min are possible. Meeting these goals has also led to advances in adsorbent-preconcentrator design, dual-column pressure/temperature-modulated separations using air as carrier gas, and vapor detection, recognition, and quantification with ultra-miniature arrays of polymer-coated surface-acoustic-wave (SAW) microsensors. Here, we propose to field test this first-generation instrument in office buildings and to explore its application for breath analysis and for industrial air monitoring where vapor concentrations tend to be higher. Development of a second-generation microanalytical system with the following refinements/additions is also proposed: a wireless interface to permit unattended operation; an on-board vapor generator for automatic field calibration and system diagnostics; use of an alternative sensor technology with greater sensitivity to reduce sample volumes and/or detection limits; addition of a focusing element to reduce inlet bandwidths and use of alternative separation strategies to improve chromatographic resolution/versatility and reduce analysis time; and implementation of Si-micromachined components to reduce size and power. Laboratory and field testing of this second-generation instrument will then be performed. This system represents a significant advancement over the current state-of-the-art in monitoring instrumentation for complex vapor mixtures, obviating the need for conventional sorbent-tube/GC-MS methods for routine indoor air (and other) monitoring. The versatility of this instrument will facilitate the assessment of exposure distributions and the implementation of rational intervention strategies related to indoor air quality and other occupational health problems.

描述：继续研究开发和实施一项 一种可现场进行形态分析的高性能微量分析系统 遇到的挥发性和半挥发性有机化合物(VOCs和SVOCs) 非工业中低/低于十亿分之一浓度的复杂混合物 提出了室内工作环境的概念。适用于其他职业 还将满足健康监测需求。在第一个发现周期中 在这个项目中，我们成功地制作和表征了表演 笔记本电脑大小的可现场使用的仪器 预浓缩、热解吸、高速可调分离以及 微传感器阵列检测。检出限为0.06-17 ppb 已经实现了跨越一年的&gt；30 VOCs/SVOCs混合物的成分 从L-L的空气样本中捕获的10,000倍的水汽压范围。响应 结合层析保留时间的模式已用于蒸气 身份证明。分析周期为10分钟是可能的。满足这些要求 Goals还推动了吸附剂-预浓缩器设计的进步，双柱 以空气和蒸汽为载气的压力/温度调制分离 利用超小型阵列进行检测、识别和量化 聚合物涂层表面声波(SAW)微传感器。在此，我们建议 这一第一代仪器在写字楼中的现场测试和探索 它在呼气分析和工业空气监测中的应用 蒸汽浓度往往更高。第二代的发展 具有以下改进/添加的微量分析系统也 建议：无线接口，允许无人值守操作；车载 自动现场校准和系统诊断用蒸汽发生器.使用 一种灵敏度更高的替代传感器技术，可减少样品 体积和/或检测极限；增加聚焦元件以减少进气量 带宽和使用替代分离策略，以提高 层析分辨率/通用性和减少分析时间；以及 实施硅微机械加工组件，以减小尺寸和功耗。 第二代仪器的实验室和现场测试将于 已执行。这一系统代表着比目前的 在监测复杂蒸汽混合物的仪器方面达到最先进水平， 不需要常规的吸收管/气相色谱-质谱法 室内空气(和其他)监测。这种乐器的多功能性将会 促进对暴露分布的评估和实施 与室内空气质量等相关的合理干预策略 职业健康问题。