权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neuro Modulated Diabetes Control (NeuMeDic): Decoding the brain and neural pathways to achieve a better control of diabetes

神经调节糖尿病控制 (NeuMeDic)：解码大脑和神经通路以更好地控制糖尿病

基本信息

批准号：
2029368
负责人：
金额：
--
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2029368
关键词：
Neuro Modulated Diabetes Control NeuMeDic

项目摘要

Diabetes is a disease caused by a breakdown in the glucose metabolic process resulting in abnormal blood glucose fluctuations. Traditionally, control has involved external insulin injection in response to elevated blood glucose to substitute the role of the beta cells in the pancreas, which would otherwise perform this function in a healthy individual. The central nervous system (CNS), however, also plays a vital role in glucose homoeostasis through the control of pancreatic secretion and insulin sensitivity which could potentially be used as a pathway for enhancing glucose control. Within this context, a novel emerging field called bioelectronic medicine, which relies on electrical modulation of the neural signals to the organs, has been introduced as an alternative treatment to using pharmaceuticals. Furthering this new emerging field, this PhD project aims at studying whether there is potential benefit of interfacing with the neural pathways through bioelectronic medicine for acquiring a tighter control of glucose levels in people with diabetes.In more detail, this PhD project aims at: i) understanding the physiological basis that underlie this neural regulation in the healthy and diabetic states in vivo (particularly during meals), ii) studying for the first time the potential benefits of modulating these neural signals in vivo for diabetes management and iii) developing novel mathematical models to be included in existing healthy and diabetes simulators. This new approach for diabetes management will have a great impact on the diabetic patients' quality of life. It will allow diabetic people to automatically maintain a better glucose control, leading to a reduction of the complications derived from its deregulation. It will also impact health care services by reducing the medical costs associated with this disease ($245 billion in US in 2012).Therefore, the proposed PhD will lead to major scientific contributions in the fields of Neurotechnology and Diabetes. This PhD is in alignment with several EPSRC research areas, including Mathematical Biology and Engineering Design.

糖尿病是一种由葡萄糖代谢过程崩溃导致的血糖异常波动引起的疾病。传统上，对照组需要在血糖升高的情况下进行外部胰岛素注射，以取代胰腺中的β细胞的作用，否则在健康的人身上就会执行这一功能。然而，中枢神经系统(CNS)也通过控制胰腺分泌和胰岛素敏感性在血糖稳态中起着至关重要的作用，这可能是一种增强血糖控制的途径。在这种背景下，一种名为生物电子医学的新兴领域被引入，它依赖于对到达器官的神经信号的电调制，作为使用药物的替代治疗。为了进一步推动这一新兴领域，该博士项目旨在研究通过生物电子医学与神经通路对接是否有潜在的好处，以获得更严格地控制糖尿病患者的血糖水平。更详细地，该博士项目旨在：i)了解在体内健康和糖尿病状态下(特别是在进餐期间)这种神经调节的生理基础，ii)首次研究在体内调节这些神经信号用于糖尿病管理的潜在好处，以及iii)开发新的数学模型，以包括在现有的健康和糖尿病模拟器中。这一新的糖尿病管理方法将对糖尿病患者的生活质量产生重大影响。它将允许糖尿病患者自动保持更好的血糖控制，从而减少因放松管制而产生的并发症。它还将通过降低与这种疾病相关的医疗成本(2012年美国为2450亿美元)来影响医疗保健服务。因此，拟议的博士学位将在神经技术和糖尿病领域产生重大科学贡献。这个博士学位与EPSRC的几个研究领域是一致的，包括数学生物学和工程设计。