Effects Of Dental Treatment During Pregnancy On Childhoo

怀孕期间牙科治疗对儿童的影响

• 批准号: 6535077
• 负责人: Dale P Sandler
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6535077
• 关键词: child physical development; clinical research; dental agent; dental amalgam; dental materials; developmental nutrition; dietary constituent; embryo /fetus toxicology; human data; iatrogenic disease; infection; longitudinal human study; mercury poisoning; methylmercury; oral health; postnatal growth disorder; pregnancy; questionnaires; umbilical cord

Aims: To evaluate the potential risks of dental treatment during pregnancy and effects on childhood development. Procedures and techniques: We are collaborating with the Avon Longitudinal Study of Pregnancy and Children (ALSPAC). They have collected data on the pregnancies of 14,000 women and their children and we are analyzing the data to look at the relationship between dental treatment during pregnancy (exposures to infection and to mercury vapor), prenatal and postnatal fish consumption and childhood development. Accomplishments: We have looked at the relationship between the questionnaire measures and umbilical cord mercury levels. There is a strong correlation between reported fish consumption and umbilical cord mercury levels, which suggests that the umbilical cord measure may be a useful measure of fetal exposure to methyl mercury. Working with Dr. Julie Daniels, who will be taking the lead on some of these analyses, we are in the process of analyzing the relationship between dental treatment during pregnancy, prenatal and postnatal fish consumption on two childhood development scales, the Denver developmental Scale and the Macarthur communication scale. Preliminary results suggest that dental mercury exposures did not have an adverse effect on child development at 18 months as assessed by these two scales. In addition, fish consumption appeared to be highly protective.

目的：评估怀孕期间牙科治疗的潜在风险以及对儿童发育的影响。程序和技术：我们正在与雅芳妊娠和儿童纵向研究（ALSPAC）合作。他们收集了14，000名妇女及其子女的怀孕数据，我们正在分析这些数据，以研究怀孕期间的牙科治疗（接触感染和汞蒸汽），产前和产后鱼类消费与儿童发育之间的关系。成果：我们研究了问卷测量值与脐带汞含量之间的关系。报告的鱼类消费量与脐带汞水平之间存在很强的相关性，这表明脐带测量可能是衡量胎儿接触甲基汞的一种有用的方法。朱莉·丹尼尔斯博士将负责其中的一些分析，我们正在与她合作，分析怀孕期间牙科治疗、产前和产后食用鱼与两种儿童发育量表（丹佛发育量表和麦克阿瑟沟通量表）之间的关系。初步结果表明，牙科汞暴露没有对儿童的发展产生不利影响，在18个月的这两个尺度评估。此外，鱼类消费似乎具有高度保护作用。