The Development of an Organ-on-a Chip Platform

器官芯片平台的开发

• 批准号: 2051172
• 金额: --
• 依托单位: Brunel University London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2051172
• 关键词: Development; Organ; Chip; Platform

Aim: This project explores an O-O-C automated platform, specifically the design, development and fabrication process of the automated platform. In order to design and develop a low cost Organ-On-a-Chip platform, 3D printing using an Ultimaker 2plus will be considered. This platform must be powered using batteries as it considers the use in 3rd world countries where power cuts may occur often. Subsequently, the design process will commence followed by embodiment, computational analysis and finally fabrication and parameter based testing of the prototype.Key research questions: This section outlines the research question that I will be answering throughout this PhD. Outlining the key research questions is vital as it sets a criterion to follow in-order to achieve the end product.How to seal the enclosure to ensure a 5% CO2 environment?How to utilize the space within the enclosure to ensure all components fit, due to the size constraint as the aim is to use an Ultimaker 2plus 3D printing machine?Investigate various methods/materials to ensure the cells can be analysed under a microscope.Which coding platform will be used to control the sensors and pump (Arduino or Raspberry Pi)?Will a GUI (Graphical User Interface) be needed to display the ambient environment within the enclosure, or to control the pump?Which power system will be used to allow the platform to last for more than 30 consecutive days?

目的：本项目探索O-O-C自动化平台，特别是自动化平台的设计、开发和制造过程。为了设计和开发低成本的单芯片器官平台，将考虑使用UltiMaker 2plus进行3D打印。这个平台必须使用电池供电，因为它考虑到在可能经常发生停电的第三世界国家使用。随后，设计过程将开始，然后是实施、计算分析，最后是原型的制造和基于参数的测试。关键研究问题：这一部分概述了我将在整个博士学位期间回答的研究问题。概述关键研究问题是至关重要的，因为它设定了一个标准来实现最终产品。如何密封外壳以确保5%的二氧化碳环境？由于尺寸限制，如何利用外壳内的空间以确保所有组件适合，因为目标是使用Ultiaker 2plus 3D打印机？研究各种方法/材料，以确保细胞可以在显微镜下进行分析。将使用哪种编码平台来控制传感器和泵(Arduino或Raspberry PI)？是否需要图形用户界面(图形用户界面)来显示外壳内的环境还是用来控制水泵？要让平台连续使用30天以上，将使用哪种动力系统？