课题基金 / 基金详情

INHALED NITRIC OXIDE

INHALED NITRIC OXIDE
吸入一氧化氮
批准号：
6661765
负责人：
WARREN Myron ZAPOL
金额：
$7.5万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
项目状态：
已结题
起止时间：
1990-07-01 至 2004-06-30
来源：
https://reporter.nih.gov/project-details/6661765
关键词：
adult respiratory distress syndrome disease /disorder model eicosanoid metabolism endotoxins enzyme activity hyperoxia hypoxia laboratory mouse nitric oxide nonhuman therapy evaluation oxidative stress pulmonary hypertension pulmonary respiration respiratory circulation respiratory gas level respiratory therapy sheep superoxide dismutase vascular endothelium vasodilation

项目摘要

项目成果

WARREN Myron ZAPOL的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The proposal is a competitive continuation of an original grant that has led to the clinical application of inhaled nitric oxide (NO) for the treatment of pulmonary hypertension. Inhaled NO will produce selective pulmonary vasodilation IN VENTILATED alveoli in some 60% of individuals without causing a fall in arterial oxygen saturation. However, 40% of patients do noT responD to NO. The investigators will study the roles of oxygen radicals and eicosanoids in hyporesponsiveness to NO. They will determine the relationship of loss of responsiveness to NO and the loss of hypoxic pulmonary vasoconstriction (HPV) in sepsis, especially as it may relate to inducible No synthase. Lastly, they will study inhalation therapy with agents that do not affect HPV and see if they are effective in enhancing gas exchange in ovine and murine lung injury models.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Inhaled nitric oxide
  • 批准号：
    7227843
  • 项目类别：
  • 资助金额：
    $35.2万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    6909827
  • 项目类别：
  • 资助金额：
    $37.13万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    7062082
  • 项目类别：
  • 资助金额：
    $36.25万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    6822755
  • 项目类别：
  • 资助金额：
    $37.03万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL