课题基金 / 基金详情

INHALED NITRIC OXIDE

INHALED NITRIC OXIDE
吸入一氧化氮
批准号：
6638288
负责人：
WARREN Myron ZAPOL
金额：
$32.36万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
项目状态：
已结题
起止时间：
1990-07-01 至 2004-06-30
来源：
https://reporter.nih.gov/project-details/6638288
关键词：
adult respiratory distress syndrome disease /disorder model eicosanoid metabolism endotoxins enzyme activity hyperoxia hypoxia laboratory mouse nitric oxide nonhuman therapy evaluation oxidative stress pulmonary hypertension pulmonary respiration respiratory circulation respiratory gas level respiratory therapy sheep superoxide dismutase vascular endothelium vasodilation

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英文摘要
The proposal is a competitive continuation of an original grant that has led to the clinical application of inhaled nitric oxide (NO) for the treatment of pulmonary hypertension. Inhaled NO will produce selective pulmonary vasodilation IN VENTILATED alveoli in some 60% of individuals without causing a fall in arterial oxygen saturation. However, 40% of patients do noT responD to NO. The investigators will study the roles of oxygen radicals and eicosanoids in hyporesponsiveness to NO. They will determine the relationship of loss of responsiveness to NO and the loss of hypoxic pulmonary vasoconstriction (HPV) in sepsis, especially as it may relate to inducible No synthase. Lastly, they will study inhalation therapy with agents that do not affect HPV and see if they are effective in enhancing gas exchange in ovine and murine lung injury models.
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Inhaled nitric oxide
  • 批准号：
    7227843
  • 项目类别：
  • 资助金额：
    $35.2万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    6909827
  • 项目类别：
  • 资助金额：
    $37.13万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    7062082
  • 项目类别：
  • 资助金额：
    $36.25万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL
Inhaled nitric oxide
  • 批准号：
    6822755
  • 项目类别：
  • 资助金额：
    $37.03万
  • 财政年份：
    1995
  • 负责人：
    WARREN Myron ZAPOL
  • 依托单位：
    MASSACHUSETTS GENERAL HOSPITAL