MAGNETIC RESONANCE STUDIES OF BONE MARROW HEMATOPOIESIS

骨髓造血的磁共振研究

• 批准号: 6530664
• 负责人: DOUGLAS J BALLON
• 金额: $ 25.54万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530664
• 关键词: acute leukemia; biomedical equipment development; blood /lymphatic neoplasm; bone marrow exam; chronic leukemia; clinical biomedical equipment; clinical research; diagnosis design /evaluation; human subject; multiple myeloma; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; nonHodgkin's lymphoma; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; phantom model; rapid diagnosis

The goals of the proposed work are to develop a non-invasive assay for characterizing hematopoieitic activity in human bone marrow, and to test its utility in monitoring and staging patients with hematologic malignancies. Presently, the needle aspirate and biopsy are used for definitive diagnosis and therapeutic monitoring. In addition to causing patient discomfort, biopsies and aspirates are limited to superficial areas of bone, such as the posterior iliac crest. The proposed assay will be designed to complement information obtained from the needle biopsy by providing a measure of the spatial extent of disease, particularly at sites inaccessible to the needle biopsy. The technical goals of the project are concerned with the development of recently introduced magnetic resonance bone marrow scanning technology. It was demonstrated that nearly complete segmentation of leukemic bone marrow was possible using a high speed magnetic resonance imaging protocol with contrast based in part upon the self-diffusion coefficient of intracellular versus extracellular water. Furthermore, the quality of the segmentation was high enough to facilitate a projection scan approach which allows a rapid assessment of extent of disease. Earlier studies of the bone marrow by magnetic resonance could not definitively detect leukemic infiltration, but rather measured changes related to bone marrow cellularity. The present effect appears to specifically screen for abnormal cells in acute lymphocytic leukemia. The research plan includes studies to 1) improve the sensitivity of the method, 2) determine the range of hematologic pathologies where it is applicable, and 3) assess its utility for patient management. Patient populations will include acute and chronic leukemia, lymphoma, multiple myeloma, and myelodysplastic syndrome. The utility of the methods will be assessed in 1) monitoring therapeutic efficacy in acute and chronic leukemia, lymphoma, and multiple myeloma, and 2) staging in chronic leukemia, lymphoma, and myelodysplastic syndrome.

拟议的工作的目标是开发一种非侵入性的检测方法来表征人骨髓中的造血活性，并测试其在血液恶性肿瘤患者的监测和分期中的实用性。 目前，针吸和活检用于明确诊断和治疗监测。 除了引起患者不适外，活检和抽吸物仅限于骨的浅表区域，例如后髂嵴。 拟定的检测试剂盒旨在通过提供疾病空间范围的测量，特别是在针吸活检无法到达的部位，补充从针吸活检获得的信息。该项目的技术目标涉及最近引进的磁共振骨髓扫描技术的发展。 结果表明，几乎完全分割白血病骨髓是可能的，使用高速磁共振成像协议与对比度的基础上的自扩散系数的细胞内与细胞外的水。 此外，分割的质量足够高，以促进投影扫描方法，该方法允许快速评估疾病的程度。早期的骨髓磁共振研究不能明确检测白血病浸润，而是测量与骨髓细胞结构相关的变化。 目前的效果似乎是专门筛选急性淋巴细胞白血病中的异常细胞。 研究计划包括以下研究：1）提高方法的灵敏度，2）确定适用的血液病理学范围，3）评估其对患者管理的效用。患者人群包括急性和慢性白血病、淋巴瘤、多发性骨髓瘤和骨髓增生异常综合征。 这些方法的效用将在以下方面进行评估：1）监测急性和慢性白血病、淋巴瘤和多发性骨髓瘤的疗效; 2）慢性白血病、淋巴瘤和骨髓增生异常综合征的分期。