Modernization and Expansion of the Citigroup Biomedical Imaging Center at Weill Cornell Medical College

摘要 拟议项目涉及重大现代化和重点建设， 位于纽约曼哈顿的威尔康奈尔医学院花旗集团生物医学成像中心（CBIC） 市CBIC是一个全面的成像研究资源，致力于开发新的 生物医学成像技术，以支持广泛的调查人员从事诊断和 治疗人类疾病。自2001年成立以来，CBIC已定期为100多名校长提供服务， 在任何一年，来自10个以上机构的调查人员（2022年来自14个机构的148个小组，我们的 有史以来最大的使用）。CBIC支持的研究具有国家和国际影响， 许多研究人员是各自学科的领导者，领导着大型的多机构研究 项目，发明新的成像技术，并在世界范围内招募人类受试者。项目范围 支持CBIC成像资源的研究非常广泛，包括神经外科，精神病学， 神经退行性疾病、肿瘤学、整形外科学、遗传医学和结构生物学。年总 美国国立卫生研究院赠款的费用通常超过5000万美元。2022年，创纪录的172个NIH资助的项目 由CBIC支持，总成本超过1.18亿美元。该中心提供十个主要的成像和 用于人体和临床前研究的光谱平台，包括磁共振成像（MRI） 和光谱学、正电子发射断层扫描（PET）、计算机断层扫描（CT）、单光子发射 计算机断层扫描、超声和光学成像。此外，完整的回旋加速器和放射化学 设施齐全。我们现在已经超过了中心成立以来的20年，我们 迫切需要进行重大的现代化和基础设施建设，以继续提供 一个安全的，最先进的环境，成像研究涉及人类受试者和动物模型， 疾病的快速增长的研究人员池。为了满足我们现在和未来的需求，我们 我提出以下五个项目组成部分：1）建设一个新的正电子发射 断层扫描/计算机断层扫描（PET/CT）套件，首次促进全身PET，2） 为我们的三个新的现代高场核磁共振（NMR）光谱套件的建设 高场核磁共振光谱仪，3）我们的放射性药物生产套件的改造，使我们能够 将生产我们高需求的碳-11标记放射性示踪剂所需的放射化学与 用其他放射性同位素生产的示踪剂，4）安装罐歧管和供应管线， 麻醉能力，使我们能够接受比目前更广泛的研究课题，5） 为两台关键扫描仪（一台MRI和一台PET）增加电气基础设施，以确保 中断被最小化，从而显著增加正在进行的和预期的图像的安全性， 指导治疗干预。

ABSTRACT The proposed project involves major modernization and focused construction at the rapidly growing Citigroup Biomedical Imaging Center (CBIC) of Weill Cornell Medical College in Manhattan, New York City. The CBIC is a comprehensive imaging research resource dedicated to the development of new biomedical imaging techniques in support of a wide range of investigators engaged in the diagnosis and treatment of human disease. Since its inception in 2001, the CBIC has routinely served over 100 Principal Investigators from more than 10 institutions in any given year (148 groups from 14 institutions in 2022, our largest usage ever). The research supported by the CBIC has both a national and international impact due to the many investigators who are leaders in their respective disciplines, lead large multi-institutional research projects, invent new imaging techniques, and recruit human subjects worldwide. The range of projects supported with CBIC imaging resources is extremely broad, and includes studies in neurosurgery, psychiatry, neurodegenerative disease, oncology, orthopedics, genetic medicine, and structural biology. The annual total costs of NIH grants that are supported typically exceeds $50 million. In 2022, a record 172 NIH funded projects were supported by CBIC with total costs of over $118 million. The Center offers ten major imaging and spectroscopy platforms for both human and pre-clinical studies, including magnetic resonance imaging (MRI) and spectroscopy, positron emission tomography (PET), computed tomography (CT), single photon emission computed tomography, ultrasound, and optical imaging. In addition, complete cyclotron and radiochemistry facilities are available. We have now surpassed the 20-year mark since the Center was established, and we have an urgent need for major modernization and construction of infrastructure in order to continue to provide a safe, state-of-the-art environment for imaging studies involving both human subjects and animal models of disease for our rapidly increasing pool of investigators. In order to meet our present and future needs, we propose the following five project components: 1) Construction of a new positron emission tomography/computed tomography (PET/CT) suite, facilitating whole-body PET for the first time, 2) construction of a new modern high field nuclear magnetic resonance (NMR) spectroscopy suite for our three high field NMR spectrometers, 3) renovation of our radiopharmaceutical production suite, allowing us to separate radiochemistry needed for production of our high demand carbon-11 labeled radiotracers from that of tracers produced with other radioisotopes, 4) installation of tank manifolds and supply lines to enable general anesthesia capability, allowing us to accept a wider range of research subjects than is currently possible, 5) addition of electrical infrastructure to two key scanners (one MRI and one PET) to ensure that transient power interruptions are minimized, thereby significantly increasing the safety of ongoing and anticipated image- guided therapeutic interventions.