Scaling up from bench-scale chemistry to continuous catalytic process using in situ magnetic resonance imaging

使用原位磁共振成像从实验室规模化学扩展到连续催化过程

• 批准号: 2073044
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2073044
• 关键词: Scaling; up; bench; scale; chemistry

Heterogeneous catalysis using precious metal supported catalysts is used routinely across the fine chemical, pharmaceutical and agrochemical industries. The chemical formulation of a given catalyst and its physical structure determine its catalytic performance. In particular, the catalyst needs to have good activity but, more importantly, high selectivity so that the production of side-products is minimised. The challenge is that while catalyst properties can be optimised at bench-scale in the development phase, the performance of the catalyst deteriorates when it is used under industrial process conditions. This is because the physical processes determining how chemical species move into and out of the catalyst, and indeed within the catalyst, change when the catalyst is used in the reactor environment and at industrial process conditions. The aim of this project is to apply the new magnetic resonance imaging measurements developed in our group to spatially map chemical conversion and the rate at which molecules move with the catalyst and reactor and to use these data to understand how these factors influence the selectivity of the reaction. This level of understanding has the potential to transform our ability to design 'greener' and more efficient catalysts for industrial processes.

使用贵金属负载催化剂的多相催化通常用于精细化工、制药和农化行业。催化剂的化学组成和物理结构决定了其催化性能。特别是，催化剂需要具有良好的活性，但更重要的是，必须具有高选择性，以便将副产品的产生降至最低。挑战在于，尽管催化剂的性能在开发阶段可以在实验室规模上进行优化，但在工业工艺条件下使用时，催化剂的性能会恶化。这是因为，当催化剂在反应器环境和工业工艺条件下使用时，决定化学物种如何进入和离开催化剂，甚至是催化剂内部的物理过程会发生变化。这个项目的目的是应用我们小组开发的新的磁共振成像测量来绘制化学转化和分子随催化剂和反应器移动的速度的空间图，并使用这些数据来了解这些因素如何影响反应的选择性。这种理解水平有可能改变我们的能力，为工业过程设计更环保、更高效的催化剂。