The Biochemistry and Cell Biology of Protein Aggregation

蛋白质聚集的生物化学和细胞生物学

• 批准号: 2074099
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2074099
• 关键词: Biochemistry; Cell; Biology; Protein; Aggregation

Family structure has been shown to impact childrens wellbeing, behavior and health outcomes. Many studies have focused on children who experience changes in family structure (ie divorce of parents or cohabitation with step-parents). However less evidence exists on health outcomes in early life and engagement with healthcare for children born to single parents. The aim of this PhD is to compare birth outcomes, mortality, and potentially preventable hospital admissions among children with single or coupled parents (married or cohabiting). Parent relationship status will be determined from birth registration data, which has been linked to Hospital Episode Statistics and mortality data for all children born in England between 2005 and 2014. A sub-study using data from an intensive home visiting intervention for teenage mothers (the Family Nurse Partnership) will also be conducted to compare health outcomes for children of young and vulnerable mothers according to maternal relationship status. Social policies to support parents differ between countries and could impact health outcomes of children. International comparisons of child health outcomes according to parental relationship status will therefore also be carried out using administrative data from up to three jurisdictions.

家庭结构已被证明会影响儿童的福祉，行为和健康结果。许多研究集中在经历家庭结构变化的儿童身上（即父母离婚或与继父母同居）。然而，关于单亲儿童早期健康状况和医疗保健参与的证据较少。该博士学位的目的是比较单亲或双亲（已婚或同居）儿童的出生结局，死亡率和潜在可预防的住院率。父母关系状况将根据出生登记数据确定，该数据已与2005年至2014年期间在英格兰出生的所有儿童的医院事件统计和死亡率数据相关联。还将进行一项子研究，利用对少龄母亲进行密集家访干预（家庭护士伙伴关系）的数据，根据母亲关系状况，比较年轻和弱势母亲的子女的健康结果。支持父母的社会政策因国家而异，可能影响儿童的健康结果。因此，还将使用最多三个司法管辖区的行政数据，根据父母关系状况对儿童健康结果进行国际比较。