The Biochemistry and Cell Biology of Protein Aggregation

家庭结构已被证明会影响儿童的福祉、行为和健康结果。许多研究集中在经历家庭结构变化的孩子身上（如父母离婚或与继父母同居）。然而，关于单亲父母所生儿童早期健康状况和参与医疗保健的证据较少。本博士的目的是比较单亲或双亲（已婚或同居）儿童的出生结果、死亡率和潜在可预防的住院情况。父母关系状况将根据出生登记数据确定，该数据与2005年至2014年间在英格兰出生的所有儿童的医院事件统计数据和死亡率数据相关联。还将进行一项子研究，利用针对青少年母亲的密集家访干预（家庭护士伙伴关系）的数据，根据母亲关系状况比较年轻和脆弱母亲的子女的健康结果。支持父母的社会政策因国家而异，可能影响儿童的健康结果。因此，还将利用最多三个司法管辖区的行政数据，根据父母关系状况对儿童健康结果进行国际比较。

Family structure has been shown to impact childrens wellbeing, behavior and health outcomes. Many studies have focused on children who experience changes in family structure (ie divorce of parents or cohabitation with step-parents). However less evidence exists on health outcomes in early life and engagement with healthcare for children born to single parents. The aim of this PhD is to compare birth outcomes, mortality, and potentially preventable hospital admissions among children with single or coupled parents (married or cohabiting). Parent relationship status will be determined from birth registration data, which has been linked to Hospital Episode Statistics and mortality data for all children born in England between 2005 and 2014. A sub-study using data from an intensive home visiting intervention for teenage mothers (the Family Nurse Partnership) will also be conducted to compare health outcomes for children of young and vulnerable mothers according to maternal relationship status. Social policies to support parents differ between countries and could impact health outcomes of children. International comparisons of child health outcomes according to parental relationship status will therefore also be carried out using administrative data from up to three jurisdictions.