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Pre-doctoral Training in Fundamental Approaches to Biochemistry and Cell and Molecular Biology

生物化学、细胞和分子生物学基础方法的博士前培训

基本信息

批准号：
10620298
负责人：
Mary Gehring
金额：
$ 159.16万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10620298
关键词：
Biochemistry Cellular biology Molecular Biology Training pre-doctoral

项目摘要

This proposal is for support of the pre-doctoral program in Cellular, Biochemical and Molecular Science at the Massachusetts Institute of Technology (MIT). Our mission is to train the next generation of biological/biomedical scientists, many of whom will be innovators and leaders in research, education, and other fields. This proposal builds on an outstanding training record developed over a 46-year partnership with NIGMS. Our aims are to: educate students to understand the fundamental and underlying principles of molecular, biochemical, and cellular biology, train students to be critical and creative thinkers, prepare students to be ethical decision makers, teach and provide practice in written and oral communication, provide experience with teaching and mentoring younger students, mentor students to become effective and rigorous researchers, guide students through completion and publication of research projects, advise students as they determine the best-fit careers for their interests and skills, provide an inclusive learning and research environment, and broaden participation of individuals with diverse backgrounds in biomedical research careers. We recruit and train talented students from majority, underrepresented minority, disabled, and disadvantaged populations. Trainees admitted to our program have outstanding academic records and strong motivation and aptitude to pursue research. A key feature of our program is an intensive, focused curriculum required of all first-year students. Students work together in lecture and discussion-style courses taught by dedicated faculty to master a fundamental set of approaches that underpin molecular biological science. The training program exposes students to the research interests of all faculty members in the Biology Department prior to a sequence of rotations that, in combination with first-semester courses, support an informed choice of a thesis advisor and topic. Students gain experience in scientific communication and in teaching and mentoring junior students. Responsible conduct of research is taught in both classroom and laboratory settings, including an intense mini-course for 2nd year students. Students have many opportunities to learn about career paths open to them following doctoral training. Students’ progress through the program is monitored in regular thesis committee meetings with faculty members, with oversight by the graduate committee. We seek to build and maintain a welcoming and supportive community in which all students are valued and included. This training grant would constitute a critical source of support for ~50% of training-grant eligible graduate students in our program during their first two years. Our students perform research of outstanding quality, and most trainees go on to careers in biomedical research. Many of our former trainees are now leaders in their chosen fields and bring to their positions the knowledge, rigor, thoughtful perspectives, and values of equity and inclusion that we emphasize at MIT Biology. We anticipate exciting futures for our alumni as they help transform the US biomedical landscape.

该提案是为了支持在细胞，生物化学和分子科学博士前计划，马萨诸塞州理工学院。我们的使命是培养下一代生物/生物医学科学家，其中许多人将是创新者和研究，教育和其他领域这项建议是建立在46年的合作伙伴关系中建立的出色培训记录的基础上的，黑鬼。我们的目标是：教育学生了解的基本和基本原则，分子，生物化学和细胞生物学，培养学生成为批判性和创造性的思想家，准备学生成为道德决策者，教授并提供书面和口头交流的实践，提供有教学和指导年轻学生的经验，指导学生变得有效和严谨研究人员，指导学生完成和发表研究项目，建议学生，因为他们确定最适合他们的兴趣和技能的职业，提供包容性的学习和研究环境，并扩大具有不同背景的个人对生物医学研究的参与 careers.我们招募和培养有才华的学生从多数，代表性不足的少数民族，残疾人，弱势群体。被录取到我们的计划的学员具有出色的学习成绩和强大的追求研究的动机和能力。我们计划的一个关键特点是密集，重点课程所有一年级学生的要求。学生们在讲座和讨论式的课程中一起工作，专门的教师掌握一套基本的方法，支持分子生物科学。的培训计划使学生接触到生物系所有教职员工的研究兴趣在与第一学期课程相结合的一系列轮换之前，论文指导老师和题目学生获得科学交流和教学经验，指导低年级学生负责任的研究行为是在课堂和实验室教授设置，包括一个激烈的迷你课程，为二年级学生。学生有很多学习的机会关于他们在博士培训后的职业道路。学生通过该计划的进展是在定期的论文委员会会议上与教职员工进行监督，由毕业生监督以马克思我们寻求建立和维护一个欢迎和支持的社区，所有学生都是重视并包括在内。这一培训赠款将构成约50%培训赠款的重要支助来源符合条件的研究生在我们的计划在他们的头两年。我们的学生进行研究，优秀的质量，大多数学员继续在生物医学研究的职业生涯。我们以前的很多学员现在是他们所选择的领域的领导者，并把他们的知识，严谨，周到公平和包容的观点和价值观，我们在麻省理工学院生物学强调。我们期待激动人心的未来为我们的校友，因为他们帮助改变美国生物医学景观。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development.

DOI：
10.1101/gr.278073.123
发表时间：
2023-09
期刊：
GENOME RESEARCH
影响因子：
7
作者：
Shi, Charlie Y.;Elcavage, Lara E.;Chivukula, Raghu R.;Stefano, Joanna;Kleaveland, Benjamin;Bartel, David P.
通讯作者：
Bartel, David P.

The Ankyrin Repeat Protein RARP-1 Is a Periplasmic Factor That Supports Rickettsia parkeri Growth and Host Cell Invasion.

锚蛋白重复蛋白 RARP-1 是一种支持帕克立克次体生长和宿主细胞侵袭的周质因子。