Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
基本信息
- 批准号:6463303
- 负责人:
- 金额:$ 38.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-04-01 至 2006-03-31
- 项目状态:已结题
- 来源:
- 关键词:behavior test behavioral /social science research tag body physical characteristic circadian rhythms clinical research electroencephalography functional ability human population study human subject neuropsychological tests neuropsychology performance polysomnography psychology sleep sleep deprivation statistics /biometry wakefulness young adult human (21-34)
项目摘要
DESCRIPTION (provided by applicant): The magnitude of neurobehavioral
performance failure during sleep deprivation varies widely among individuals,
and there are marked inter-individual differences in the structure of
subsequent recovery sleep as well. Using a repeated total sleep deprivation
(TSD) paradigm, the proposed project seeks to quantify the trait component of
inter-individual differences in the response to sleep loss. In order to examine
the malleability of the trait component, the magnitude of the trait component
will also be compared with the magnitude of the response to a change in
workload state. In addition, potential predictors of individual responses to
sleep loss will be identified. A total of n=39 subjects will be exposed, on
three consecutive occasions, to 36 hours of controlled TSD in a laboratory.
Each 36-hour TSD will be followed by two 12-hour recovery sleep opportunities.
Throughout the experiment, waking neurobehavioral performance will be monitored
every two hours at fixed times by means of standardized behavioral tests, while
baseline and recovery sleep will be studied with polysomnography (PSG) and
electroencephalogram (EEG) power-spectral analysis. For each subject, two of
the three TSD periods will involve moderate workload, while the other TSD
period will have high (i.e. double-duration) workload, in randomized
counterbalanced order.
The investigation has five specific aims: (1) Quantify the magnitude and
importance of inter-individual variability in neurobehavioral performance
failure during TSD and the structure of subsequent recovery sleep; (2) Quantify
the extent to which neurobehavioral performance failure during TSD involves a
trait response and/or a state response to workload; (3) Quantify the extent to
which the structure of recovery sleep following TSD involves a trait response
and/or a state response to prior workload; (4) Explore the relationship between
individuals' magnitude of neurobehavioral performance failure during TSD and
the structure of their subsequent recovery sleep; and (5) Identify predictors
of individuals' magnitude of neurobehavioral performance failure during TSD and
the structure of their subsequent recovery sleep, by examining six predictor
domains: baseline neurobehavioral performance, baseline sleep architecture,
circadian rhythmicity, physical characteristics, psychological parameters, and
demographic statistics. The results of this investigation will fill a critical
gap in our understanding of inter-individual differences in the response to
sleep loss, and the factors that determine these differences. The research will
be relevant for the understanding, remediation and prevention of the
potentially serious effects of sleep deprivation in the millions of individuals
who are occasionally or routinely exposed to sleep loss due to medical
condition, occupation or lifestyle.
描述(由申请人提供):神经行为的大小
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hans P A Van Dongen其他文献
Hans P A Van Dongen的其他文献
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{{ truncateString('Hans P A Van Dongen', 18)}}的其他基金
\"Innovations in Research and Practice Improving Shiftworker Health and Safety\" - the 24th International Shiftwork and Working Time Symposium
“改善轮班工人健康与安全的研究与实践创新”——第24届国际轮班工作与工作时间研讨会
- 批准号:
9761867 - 财政年份:2019
- 资助金额:
$ 38.33万 - 项目类别:
INDIVIDUAL DIFFERENCES IN RESPONSE TO SLEEP DEPRIVATION
对睡眠剥夺的反应存在个体差异
- 批准号:
7199068 - 财政年份:2004
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
7039624 - 财政年份:2003
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
6858785 - 财政年份:2002
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
6798446 - 财政年份:2002
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
6623129 - 财政年份:2002
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
7100844 - 财政年份:2002
- 资助金额:
$ 38.33万 - 项目类别:
Individual Differences in Response to Sleep Deprivation
对睡眠不足反应的个体差异
- 批准号:
6742523 - 财政年份:2002
- 资助金额:
$ 38.33万 - 项目类别:














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