Individual Differences in Response to Sleep Deprivation

描述(申请人提供)：神经行为的大小 在睡眠剥夺期间的表现失败在不同的人之间差异很大， 并且在结构上存在显著的个体差异 随后的恢复睡眠也是如此。使用重复的完全睡眠剥夺 (TSD)范式，拟议的项目试图量化 个体间对失眠反应的差异。为了检查 特征成分的延展性、特征成分的大小 也将与对变化的反应的幅度进行比较 工作负载状态。此外，个体反应的潜在预测因素 睡眠不足将被识别出来。总共n=39名受试者将被曝光，在 连续三次，在实验室中控制36小时的TSD。 每一次36小时的TSD之后将有两次12小时的恢复睡眠机会。 在整个实验过程中，将监测清醒的神经行为表现 通过标准化的行为测试，每两个小时在固定的时间，而 基础睡眠和恢复睡眠将通过多导睡眠图(PSG)和 脑电功率谱分析。对于每个科目，有两个 三个TSD期间将涉及中等工作负载，而其他TSD期间 期间将具有高(即双倍持续时间)的工作负载，在随机情况下 平衡秩序。 调查有五个具体目标：(1)量化规模和 个体间差异在神经行为表现中的重要性 TSD期间的故障和后续恢复睡眠的结构；(2)量化 在TSD期间神经行为表现失败的程度涉及 特质反应和/或对工作负荷的状态反应；(3)量化程度 TSD后的恢复睡眠结构与特质反应有关 和/或对先前工作负荷的状态响应；(4)探索 在TSD和TSD期间个体神经行为表现失败的程度 他们随后恢复睡眠的结构；以及(5)确定预测因素 在TSD和TSD期间个体神经行为表现失败的程度 他们随后恢复睡眠的结构，通过检查六个预测因素 领域：基线神经行为表现，基线睡眠结构， 昼夜节律性、生理特征、心理参数和 人口统计数据。这项调查的结果将填补一个关键的 我们对应对的个体间差异的理解存在差距 睡眠不足，以及决定这些差异的因素。这项研究将 与了解、补救和预防 睡眠剥夺对数百万人的潜在严重影响 偶尔或经常因健康问题而失眠的人 条件、职业或生活方式。

DESCRIPTION (provided by applicant): The magnitude of neurobehavioral performance failure during sleep deprivation varies widely among individuals, and there are marked inter-individual differences in the structure of subsequent recovery sleep as well. Using a repeated total sleep deprivation (TSD) paradigm, the proposed project seeks to quantify the trait component of inter-individual differences in the response to sleep loss. In order to examine the malleability of the trait component, the magnitude of the trait component will also be compared with the magnitude of the response to a change in workload state. In addition, potential predictors of individual responses to sleep loss will be identified. A total of n=39 subjects will be exposed, on three consecutive occasions, to 36 hours of controlled TSD in a laboratory. Each 36-hour TSD will be followed by two 12-hour recovery sleep opportunities. Throughout the experiment, waking neurobehavioral performance will be monitored every two hours at fixed times by means of standardized behavioral tests, while baseline and recovery sleep will be studied with polysomnography (PSG) and electroencephalogram (EEG) power-spectral analysis. For each subject, two of the three TSD periods will involve moderate workload, while the other TSD period will have high (i.e. double-duration) workload, in randomized counterbalanced order. The investigation has five specific aims: (1) Quantify the magnitude and importance of inter-individual variability in neurobehavioral performance failure during TSD and the structure of subsequent recovery sleep; (2) Quantify the extent to which neurobehavioral performance failure during TSD involves a trait response and/or a state response to workload; (3) Quantify the extent to which the structure of recovery sleep following TSD involves a trait response and/or a state response to prior workload; (4) Explore the relationship between individuals' magnitude of neurobehavioral performance failure during TSD and the structure of their subsequent recovery sleep; and (5) Identify predictors of individuals' magnitude of neurobehavioral performance failure during TSD and the structure of their subsequent recovery sleep, by examining six predictor domains: baseline neurobehavioral performance, baseline sleep architecture, circadian rhythmicity, physical characteristics, psychological parameters, and demographic statistics. The results of this investigation will fill a critical gap in our understanding of inter-individual differences in the response to sleep loss, and the factors that determine these differences. The research will be relevant for the understanding, remediation and prevention of the potentially serious effects of sleep deprivation in the millions of individuals who are occasionally or routinely exposed to sleep loss due to medical condition, occupation or lifestyle.