Building stronger synapses: investigation of the structural role of CaMKII in long-term potentiation

构建更强的突触：研究 CaMKII 在长时程增强中的结构作用

• 批准号: 2081382
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2081382
• 关键词: Building; stronger; synapses; investigation; structural

Long-term potentiation (LTP) of synaptic connections between neurons is a fundamental mechanism for learning and memory. In most synapses, highly abundant calmodulindependent protein kinase II (CaMKII) plays an essential role by linking large influxes of calcium to phosphorylation of ion channels embedded in the postsynaptic membrane. In addition to its enzymatic role, CaMKII accumulates in dendritic spines during LTP induction, where it establishes molecular interactions that maintain the synapse in a potentiated state. The aim of this project is to understand how CaMKII fulfils this poorly understood latter role by combining chemical, structural, physiological, and computational approaches.

神经元之间突触连接的长时程增强（LTP）是学习和记忆的基本机制。在大多数突触中，高度丰富的钙调素非依赖性蛋白激酶II（CaMK II）通过将大量钙流入与嵌入突触后膜的离子通道磷酸化联系起来而发挥重要作用。除了其酶促作用外，CaMKII在LTP诱导期间在树突棘中积累，在那里它建立维持突触处于增强状态的分子相互作用。该项目的目的是了解CaMKII如何通过结合化学，结构，生理和计算方法来实现这一知之甚少的后一种作用。