DEVELOPMENT OF DRUG ABUSE&DELINQUENCY IN ADHD ADOLESCENT

药物滥用的发展

• 批准号: 6538385
• 负责人: ANDY LOPEZ-WILLIAMS
• 金额: $ 2.61万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6538385
• 关键词: adolescence (12-20); attention deficit disorder; behavior prediction; behavioral /social science research tag; clinical research; comorbidity; conduct disorder; disease /disorder proneness /risk; drug abuse; human subject; juvenile delinquency; postdoctoral investigator; young adult human (21-34)

Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with significantly impairing levels of over activity, impulsivity, and inattention, which can deleteriously affect social and academic domains of functioning. Although the extant evidence is abundant regarding the short-term impairments associated with ADHD, the evidence is mixed regarding the predictive risk for drug abuse and juvenile delinquency/adult criminality associated with ADHD. The proposed research is aimed toward understanding the risks and impairments associated with ADHD alone and when co-morbid for CD and non- ADHD comparisons. The specific aims of the proposed research are 1) to gauge the hypothesized differential risk for children with ADHD alone and co-morbid with CD in key domains (e.g., alcohol and other drug use, delinquency), 2) to identify subsets of children (e.g., ADHD subtypes, groups based upon demographic factors and parental factors) that may be at higher risk drug abuse and juvenile delinquency/adult criminality. Current information regarding drug abuse and delinquent and criminal offenses will be gathered from a sample of 500 ADHD children who attended a summer camp for treatment of disruptive behavior disorders when they were between the ages of 6-12 years of a comparison sample of 200 non-ADHD adolescents matched for age, gender, and SES. The ADHD sample will be divided into three developmental stages: early adolescence, mid-to-late adolescence and young adulthood. Because of the large sample size and the availability of diagnostic information gathered while the sample was of elementary school ages, this proposed research will be of especially important in 1) clarifying the conflicting evidence regarding risk for alcohol and other drug abuse and juvenile delinquency/adult criminality associated with ADHD and CD independently and co-morbidity, and 2) identifying other demographic and parental factors that may increase children's risk for drug abuse and juvenile delinquency/adult criminality above and beyond the risk associated with ADHD and CD independently and co-morbidity.

注意缺陷/多动障碍（ADHD）与过度活动、冲动和注意力不集中的显著损害水平有关，这会对社会和学术功能领域产生有害影响。虽然现有的证据是充分的关于ADHD相关的短期损害，证据是混合的关于药物滥用和青少年犯罪/成人犯罪与ADHD相关的预测风险。拟议的研究旨在了解与ADHD单独相关的风险和损害，以及与乳糜泻和非ADHD合并症的比较。该研究的具体目的是：1)衡量单独患有ADHD和合并患有CD的儿童在关键领域（如酒精和其他药物使用、犯罪）的假设差异风险；2)确定可能具有较高药物滥用和青少年犯罪/成人犯罪风险的儿童亚群（如ADHD亚型、基于人口统计学因素和父母因素的群体）。有关药物滥用、犯罪和刑事犯罪的最新信息将从500名ADHD儿童样本中收集，这些儿童在6-12岁之间参加了破坏性行为障碍治疗夏令营，与200名年龄、性别和社会地位相匹配的非ADHD青少年样本进行比较。ADHD样本将被分为三个发展阶段：青春期早期、青春期中后期和成年早期。由于样本量大，而且样本是在小学年龄时收集的诊断信息的可用性，这项拟议的研究将特别重要：1)澄清关于酒精和其他药物滥用风险以及与ADHD和CD单独和共发病相关的青少年犯罪/成人犯罪的相互矛盾的证据；2)确定可能增加儿童药物滥用和青少年犯罪/成人犯罪风险的其他人口统计学和父母因素，这些因素超出了与ADHD和CD单独和共发病相关的风险。