DEVELOPMENT OF DRUG ABUSE&DELINQUENCY IN ADHD ADOLESCENT

药物滥用的发展

• 批准号: 6638928
• 负责人: ANDY LOPEZ-WILLIAMS
• 金额: $ 2.79万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6638928
• 关键词: adolescence (12-20); attention deficit disorder; behavior prediction; behavioral /social science research tag; clinical research; comorbidity; conduct disorder; disease /disorder proneness /risk; drug abuse; human subject; juvenile delinquency; postdoctoral investigator; young adult human (21-34)

Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with significantly impairing levels of over activity, impulsivity, and inattention, which can deleteriously affect social and academic domains of functioning. Although the extant evidence is abundant regarding the short-term impairments associated with ADHD, the evidence is mixed regarding the predictive risk for drug abuse and juvenile delinquency/adult criminality associated with ADHD. The proposed research is aimed toward understanding the risks and impairments associated with ADHD alone and when co-morbid for CD and non- ADHD comparisons. The specific aims of the proposed research are 1) to gauge the hypothesized differential risk for children with ADHD alone and co-morbid with CD in key domains (e.g., alcohol and other drug use, delinquency), 2) to identify subsets of children (e.g., ADHD subtypes, groups based upon demographic factors and parental factors) that may be at higher risk drug abuse and juvenile delinquency/adult criminality. Current information regarding drug abuse and delinquent and criminal offenses will be gathered from a sample of 500 ADHD children who attended a summer camp for treatment of disruptive behavior disorders when they were between the ages of 6-12 years of a comparison sample of 200 non-ADHD adolescents matched for age, gender, and SES. The ADHD sample will be divided into three developmental stages: early adolescence, mid-to-late adolescence and young adulthood. Because of the large sample size and the availability of diagnostic information gathered while the sample was of elementary school ages, this proposed research will be of especially important in 1) clarifying the conflicting evidence regarding risk for alcohol and other drug abuse and juvenile delinquency/adult criminality associated with ADHD and CD independently and co-morbidity, and 2) identifying other demographic and parental factors that may increase children's risk for drug abuse and juvenile delinquency/adult criminality above and beyond the risk associated with ADHD and CD independently and co-morbidity.

注意力缺陷/多动障碍（ADHD）与过度活动，冲动和注意力不集中的严重损害水平有关，这可能会对社会和学术领域的功能产生不利影响。虽然关于ADHD相关的短期损害的现有证据是丰富的，但关于ADHD相关的药物滥用和青少年犯罪/成人犯罪的预测风险的证据是混合的。拟议的研究旨在了解与ADHD单独相关的风险和损害，以及CD和非ADHD比较的共病时的风险和损害。拟议研究的具体目的是：1）在关键领域（例如，酒精和其他药物使用，青少年犯罪），2）识别儿童的子集（例如，ADHD亚型，基于人口统计学因素和父母因素的群体）可能处于较高的药物滥用和青少年犯罪/成人犯罪风险。目前有关药物滥用和违法犯罪和刑事犯罪的信息将从500名ADHD儿童的样本中收集，这些儿童在6-12岁之间参加了一个夏令营，以治疗破坏性行为障碍，并与200名年龄，性别和SES匹配的非ADHD青少年进行比较。ADHD样本将分为三个发展阶段：青春期早期，青春期中后期和青年期。由于样本量大，并且在样本为小学年龄时收集的诊断信息可用，因此这项拟议的研究将在以下方面特别重要：1）澄清关于酒精和其他药物滥用以及与ADHD和CD独立相关的青少年犯罪/成人犯罪风险的相互矛盾的证据以及合并症，以及2）确定可能增加儿童药物滥用和青少年犯罪/成人犯罪风险的其他人口统计学和父母因素，这些因素超过与ADHD和CD独立和共病相关的风险。