Model of Traumatic Brain Injury Treatment

描述(申请人提供)：本研究旨在测试 一种非侵入性的方法，用于将生长因子定点输送到 受创伤的大脑。包括神经生长在内的各种神经营养因子 神经生长因子、脑源性神经营养因子与胰岛素样生长 胰岛素样生长因子(IGF-1)已被证明可显著减轻神经细胞的损失 以及与创伤性脑损伤(TBI)相关的行为缺陷。 神经营养因子尚未被开发为人类的治疗药物，因为 给药时出现的严重副作用 从系统上讲。我们实验室的初步结果表明， 我们的系统在防止脑损伤模型中细胞死亡方面的潜力。在这 提议，我们将使用运营商将NGF、BDNF和IGF-1传输到特定的 用于治疗受损或退化的神经元的大脑中的部位。 这项工作是为更一般的工作设计系统的一个模型 大脑内许多药物和分子的特定部位递送。我们 已经完成了一项试点工作，展示了使用NGF提高细胞存活率 治疗。在快速通道提案的第一阶段中，我们将获得剂量水平 将药物转移到大脑中的特定部位，建立起 我们独特的化合物，并决定我们能够达到特定的 毒品投放的目标地点。

DESCRIPTION (provided by applicant):This research is to test implementation of a non-invasive method for site-specific delivery of growth factors to the traumatically injured brain. Various neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and insulin like growth factor (IGF-1) have been shown to significantly attenuate neuronal cell loss and behavioral deficits associated with traumatic brain injury (TBI). Neurotrophins have not been developed as treatments in humans because of the significant side effects encountered when the drugs are administered systemically. Preliminary results from our laboratory have demonstrated the potential of our system to prevent cell death in a brain injury model. In this proposal, we will use a carrier to transport NGF, BDNF, and IGF-1 to specific sites within the brain as treatment for injured or degenerating neurons. This work is a model for a more general effort to design a system for site-specific delivery for a number of drugs and molecules within the brain. We have completed a pilot effort demonstrating improved cell survival with NGF treatment. In this Phase I of a Fast Track proposal we wilt obtain dose levels of drug to specific sites within the brain, establish the biologic activity of our unique compounds, and determine that we are able to reach the specific sites targeted for drug delivery.