The genomic evolution of primate craniofacial anatomy

灵长类颅面解剖的基因组进化

• 批准号: 2087520
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2087520
• 关键词: genomic; evolution; primate; craniofacial; anatomy

In primates, craniofacial variation provides fundamental cues for individual and species identification. Several genome-wide studies have identified variants that influence facial morphology in humans, including some variants with large effects. Beyond identifying variants that contribute to craniofacial diversity, these studies point to the genes that are responsible for different aspects of face morphology. Drawing from those studies, we will investigate the evolution of genes involved in craniofacial phenotypic variation in humans and other primates. This study will test whether face heterogeneity across individuals is adaptive, and whether species-specific craniofacial configurations are driven by natural selection.

在灵长类动物中，颅面的变化为个体和物种识别提供了基本线索。几项全基因组研究已经确定了影响人类面部形态的变异，包括一些影响较大的变异。除了确定有助于颅面多样性的变异之外，这些研究还指出了负责面部形态不同方面的基因。从这些研究中，我们将调查在人类和其他灵长类动物的颅面表型变异涉及的基因的进化。这项研究将测试个体之间的面部异质性是否具有适应性，以及物种特定的颅面配置是否由自然选择驱动。