Regional Brain Activity Estimation from M/EEG Data

根据 M/EEG 数据估计区域大脑活动

• 批准号: 6550691
• 负责人: Mark E Pflieger
• 金额: $ 37.43万
• 依托单位: SOURCE SIGNAL IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550691
• 关键词: bioimaging /biomedical imaging; brain disorder diagnosis; brain electrical activity; brain imaging /visualization /scanning; brain mapping; clinical research; computer assisted diagnosis; computer data analysis; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; electroencephalography; epilepsy; functional magnetic resonance imaging; human data; magnetoencephalography; neurosciences; noninvasive diagnosis

DESCRIPTION (provided by applicant): Multimodal dynamic functional brain imaging comprises a set of hardware and software tools intended to permit researchers and clinicians to study where and when events occur in the brain. REGAE (regional activity estimation) is a feasible and promising new methodology for estimating fast neuroelectric activity that originates in one or more brain regions of interest (ROls), and has the potential to extend existing functional imaging methods. The REGAE method is based on the combination of imaging and electrophysiological (EEG or MEG) data, using advanced statistical analysis tools. Both spatial resolution and RO1 signal detectability are quantifiable within the REGAE framework, within which an estimator's sensitivity to modeling and measurement errors can be characterized. The overall aim of Phase II is to push forward with theoretical advancement, sensitivity studies, and real-world evaluations of REGAE in order to develop a commercially successful software component that integrates with existing EMSE Suite software. The intended market areas for REGAE are: (i) basic research in human brain mapping and cognitive neuroscience, (ii) preclinical research in neuropsychiatry and neurology, and, most specifically, (iii) clinical application in presurgical evaluations for intractable epilepsy.

描述（由申请人提供）：多模态动态功能性脑成像包括一组硬件和软件工具，旨在允许研究人员和临床医生研究大脑中事件发生的地点和时间。 REGAE（区域活动估计）是一种可行且有前途的新方法，用于估计源自一个或多个感兴趣的大脑区域（ROls）的快速神经电活动，并且有可能扩展现有的功能成像方法。 REGAE 方法基于成像和电生理（EEG 或 MEG）数据的结合，并使用先进的统计分析工具。空间分辨率和 RO1 信号可检测性都可以在 REGAE 框架内量化，在该框架内可以表征估计器对建模和测量误差的敏感度。第二阶段的总体目标是推进 REGAE 的理论进步、敏感性研究和实际评估，以开发与现有 EMSE Suite 软件集成的商业成功的软件组件。 REGAE 的预期市场领域是：（i）人脑图谱和认知神经科学的基础研究，（ii）神经精神病学和神经病学的临床前研究，以及（iii）顽固性癫痫术前评估的临床应用。