Advances in Nanostructural Genomics II

描述（由申请人提供）：本申请是为了部分支持将于2002年10月3日至6日在缅因州巴尔港的杰克逊实验室举行的“纳米结构蛋白质组学进展II”会议。正如完整的基因列表将促进人类遗传疾病的诊断和治疗一样，对基因组结构和功能的深入了解将为理解发育和疾病的分子基础奠定坚实的基础。越来越多的证据表明，基因在染色体上和在细胞核内的位置会影响它的激活。与此同时，越来越多的人认识到，控制表达的顺式作用序列也会影响基因在细胞核中的空间位置，以及它与转录不活跃或允许的染色质结构域的关联。因此，导致细胞核中基因差异排列的局部和高阶相互作用有可能对建立细胞类型特异性基因表达的全局模式做出重大贡献。在这方面，目前用于研究大规模核结构的任何方法学方法都可能对中尺度特别是纳米尺度上的基因组结构研究非常有用。此外，利用同步辐射的新技术和纳米技术产生的新标记为研究基因组纳米结构提供了有效的工具。

DESCRIPTION (provided by applicant): This application is for partial support of the meeting "Advances in Nanostructural Proteomics II" to be held at The Jackson Laboratory in Bar Harbor Maine on October 3-6, 2002. Just as the complete gene list will advance the diagnosis and treatment of human genetic disorders, insight into genome structure and function will constitute a solid foundation for understanding the molecular basis of development and disease. There is rapidly growing evidence that the position of a gene on a chromosome and within the nucleus influences its activation. This is accompanied by increasing recognition that the cis-acting sequences that control expression also affect the spatial position of a gene in the nucleus and its association with transcriptionally inactive or permissive chromatin domains. Thus, local and higher order interactions that result in the differential arrangement of genes in the nucleus have the potential to make a substantial contribution to the establishment of global patterns of cell type specific gene expression. In this regard, any of the methodological approaches currently used to approach large-scale nuclear architecture may be highly useful also to study genome structure at the mesoscale and especially at the nanoscale level. In addition, new techniques using synchrotron radiation and new markers produced by nanotechnology methods are providing efficient tools to study the genome nanostructure. This meeting will provide a forum for an interdisciplinary discussion on the short and long-term research goals for correlating genuine architecture with biological function. A focused approach connecting biology, nanotechnology, and mathematical modeling is required to make rapid progress in this fundamental and important research area. We anticipate that worldwide leading scientists in the disciplines needed for a comprehensive approach to functional genomics will participate in the discussions. The meeting, first held in October of 2001, has become the springboard for the newly formed "Genome Architecture Consortium" which will continue to produce reports identifying the research needs, opportunities, and challenges in determining and understanding the structure of the genome and its relationship to biological function.