Meetings on Advances in Nanostructural Genomics

纳米结构基因组学进展会议

• 批准号: 6709768
• 负责人: Timothy Paul O'Brien
• 金额: $ 0.5万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-26 至 2004-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6709768
• 关键词: functional /structural genomics; meeting /conference /symposium; nanotechnology; travel

DESCRIPTION: (provided by applicant) This application is for 5 years of partial support for the meeting "Advances in Nanostructural Genomics" held at annually at The Jackson Laboratory in Bar Harbor, Maine. The primary objective of these meetings is to recruit the interest and participation of researchers from the multiple disciplines that must be brought to bear on solving complex biological problems in this area. Just as the complete gene list will advance the diagnosis and treatment of human genetic disorders, insight into genome structure and function will constitute a solid foundation for understanding the molecular basis of development and disease. Biophysical, chemical and nanoscience approaches to the study of nuclear genome structure and activity have been recently developing and hold considerable promise in this area. A selection of fundamental problems in genome organization and function will be reviewed and discussed in the context of new perspectives and approaches across several disciplines. Advancing these concepts and solving such complex biological problems will require coordinated networks of physicists, chemists and materials scientists collaborating with cell, developmental and genome biologists. In this regard, many of the methodological approaches currently used to approach large-scale nuclear architecture may be highly useful also to study genome structure at the mesoscale and especially at the nanoscale level. This meeting will provide a forum for an interdisciplinary discussion on the short and long-term research goals for correlating genome architecture with biological function. A focused approach connecting biology, nanotechnology, and mathematical modeling is required to make rapid progress in this fundamental and important research area. We anticipate that worldwide leading scientists in the disciplines needed for a comprehensive approach to functional genomics will participate in the discussions. This meeting, first held in October of 2001, has become the springboard for the newly formed "Genome Architecture Consortium", a multidisciplinary core of investigators which has, and will continue to, produce reports identifying the research needs, opportunities, and challenges in determining and understanding the structure of the genome and its relationship to biological function. The 2003 meeting will be held on October 16-19.

产品说明：（由申请人提供）本申请是对在缅因州巴尔港的杰克逊实验室每年举行的“纳米结构基因组学进展”会议的5年部分支持。这些会议的主要目标是吸引必须解决这一领域复杂生物学问题的多学科研究人员的兴趣和参与。正如完整的基因列表将推进人类遗传疾病的诊断和治疗一样，对基因组结构和功能的深入了解将为理解发育和疾病的分子基础奠定坚实的基础。生物物理，化学和纳米科学的方法来研究核基因组的结构和活动最近一直在发展，并在这一领域有相当大的希望。在基因组的组织和功能的基本问题的选择将审查和讨论的背景下，新的观点和方法跨越几个学科。推进这些概念并解决如此复杂的生物学问题将需要物理学家，化学家和材料科学家与细胞，发育和基因组生物学家合作的协调网络。在这方面，目前用于接近大规模核结构的许多方法学途径也可能非常有用，以研究基因组结构在中尺度，特别是在纳米级水平。 本次会议将提供一个跨学科讨论的论坛，讨论基因组结构与生物功能相关的短期和长期研究目标。一个集中的方法连接生物学，纳米技术和数学建模需要在这个基础和重要的研究领域取得快速进展。我们预计，功能基因组学综合方法所需学科的世界领先科学家将参与讨论。该会议于2001年10月首次举行，现已成为新成立的“基因组结构联盟”的跳板，该联盟是一个多学科的研究人员核心， 继续编写报告，确定在确定和理解基因组结构及其与生物功能的关系方面的研究需求、机遇和挑战。2003年会议将于10月16日至19日举行。

项目成果

Genome function and nuclear architecture: from gene expression to nanoscience.

基因组功能和核结构：从基因表达到纳米科学。

• DOI: 10.1101/gr.946403
• 发表时间: 2003
• 期刊: Genome research
• 影响因子: 7
• 作者: O'Brien,TimothyP;Bult,CarolJ;Cremer,Christoph;Grunze,Michael;Knowles,BarbaraB;Langowski,Jorg;McNally,James;Pederson,Thoru;Politz,JoanC;Pombo,Ana;Schmahl,Gunter;Spatz,JoachimP;vanDriel,Roel
• 通讯作者: vanDriel,Roel