Conference--Genomics Meets Nanoscience

描述（由申请人提供）：本申请是部分支持 在杰克逊实验室举行的“基因组学与纳米科学”会议 在缅因州的巴尔港，2001年10月9-12日。许多方法论 目前用于研究大型核结构的方法可能是 也非常有用的研究基因组结构在中尺度，特别是在 纳米尺度此外，使用同步辐射的新技术和新的 由纳米技术方法产生的标记物提供了有效的工具， 研究基因组纳米结构。一个重要的问题是， 基因组纳米结构不仅可以在固定细胞的细胞核中进行分析， 而且在体内也是如此。这将为研究 活细胞中的单个基因，并允许回答这个问题， 基因的转录激活和永久沉默是可重复的 与特定基因的重新定位有关。例如已经 证明了某些基因在转录时是活跃的， 位于远离着丝粒异染色质的位置，但在 募集到着丝粒异染色质块。 本次会议将提供一个论坛，就 基因组纳米级结构相关的短期和长期研究目标 具有生物功能。一个专注的方法连接生物学， 纳米技术和数学建模需要取得迅速进展， 这是一个非常重要的研究领域。我们预计， 在学科的领先科学家需要一个全面的方法， 功能基因组学将参与讨论。会议将 编写一份报告，确定研究需求、机遇和挑战 在确定和理解基因组的结构及其 与生物功能的关系。此报告将在 会议结束后立即举行为期两天的特别会议。

DESCRIPTION (provided by applicant): This application is for partial support of the meeting "Genomics Meets Nanoscience" to be held at The Jackson Laboratory in Bar Harbor, Maine on October 9-12, 2001. Many of the methodological approaches currently used to approach large-scale nuclear architecture may be highly useful also to study genome structure at the mesoscale and especially at the nanoscale. In addition, new techniques using synchrotron radiation and new markers produced by nanotechnology methods are providing efficient tools to study the genome nanostructure. An important topic is the question as to what extent genome nanostructure can be analyzed not only in nuclei of fixed cells but also in vivo. This would open the possibility of studying movements of individual genes in living cells and allow an answer to the question of whether transcriptional activation and permanent silencing of genes is reproducibly correlated with a repositioning of particular genes. For example, it has been demonstrated that certain genes are transcriptionally active when they are positioned away from centromeric heterochromatin, but become silenced following recruitment to centromeric heterochromatin blocks. This meeting will provide a forum for an interdisciplinary discussion on the short and long-term research goals for correlating genome nanoscale structure with biological function. A focused approach connecting biology, nanotechnology, and mathematical modeling is required to make rapid progress in this fundamental and important research area. We anticipate that worldwide leading scientists in the disciplines needed for a comprehensive approach to functional genomics will participate in the discussions. The meeting will produce a report identifying the research needs, opportunities, and challenges in determining and understanding the structure of the genome and its relationship to biological function. This report will be generated during a special two-day session immediately following the meeting.