Calcium Oxalate in Biological Systems

描述（由申请人提供）： 这是一份为FASEB夏季会议提供部分支持的资金申请，该会议于2002年8月3日至8日在佛蒙特州萨克顿河的佛蒙特学院举行，题为“生物系统中的草酸钙”。这次会议是关于这个主题的第一次FASEB夏季会议的续集，这次会议非常成功，随后在参加的不同科学家之间传播了新发现的同事之间的合作。也许钙和草酸盐络合的最有趣和神秘的方面是，它对植物生命的正常生理至关重要，而在人类和动物中，它的主要重要性来自于它在肾结石疾病的病理生理学中的作用。植物和动物生理学之间的这种功能对比突出了本次会议的一个重要特点。与可以降解草酸盐的细菌和真菌相反，哺乳动物细胞在这方面没有能力。显然，当来自广泛学科的如此多样化的研究人员讨论这一专题时，交流和相互促进思想的潜力是巨大的。本次会议已专门计划包括年轻/新的研究人员，因为草酸钙研究领域最令人兴奋和快速的增长是在解决一些困扰的问题和问题，直到现在仍然难以捉摸的新技术的应用。预计约有150名科学家将出席第二次会议。目前，50%的演讲者/会议主席是年轻的新研究人员/新参与者，其余的是在各自研究领域备受尊敬和认可的个人。将举行九场科学会议，主题如下：1）导致草酸盐形成的代谢途径; 2）细胞对草酸盐/前体的处理; 3）草酸钙结晶过程; 4）草酸钙晶体抑制; 5）晶体和细胞相互作用; 6）草酸盐和草酸钙的细胞反应; 7）遗传方面; 8）结石病的病理生理学; 9）整合来自不同系统的信息。本次会议的总体目标是提供一个论坛，使草酸钙研究领域的不同科学家能够在完全不同的科学学科中收集和分享广泛的知识。没有其他地方可以让植物学家、泌尿科医生和化学工程师（仅举15个学科中的3个）聚集在同一个地点，从各自的角度讨论同一个话题。在我们看来，本次会议的特点是强调了最后一次计划会议，承认我们可以集体地相互学习，把一个多学科的方法，以科学的讨论和实验。

DESCRIPTION (provided by applicant): This is an application for funds to provide partial support for a FASEB Summer Conference entitled: "Calcium Oxalate in Biological Systems" at the Vermont Academy in Saxtons River, Vermont, on August 3-8, 2002. This Conference is a sequel to the first FASEB Summer Conference on this topic which was very successful and subsequently propagated collaborations between newly found colleagues among the diverse scientists who attended. Perhaps the most intriguing and enigmatic aspect of the complexation of calcium and oxalate is the fact that it is crucial to the normal physiology of plant life, whereas in humans and animals, its primary importance is derived from its role in the pathophysiology of kidney stone disease. This contrast in function between plant and animal physiology highlights one of the important features of this Conference. In contrast to bacteria and fungi that can degrade oxalate, mammalian cells have no capacity in this regard. Clearly, there is tremendous potential for both exchange and cross-fertilization of ideas when the topic is discussed by such a diverse group of investigators from a wide range of disciplines. This conference has been specifically planned to include young/new investigators since the most exciting and rapid growth in the area of calcium oxalate research is in the application of newer technology in addressing some of the nagging questions and issues that have remained elusive up until now. Approximately 150 scientists are expected to attend this second Conference. Presently, 50% of the Speakers/Session Chairs are young new researchers/new participants to this Summer Conference and the remainder are individuals who are highly respected and recognized in their respective areas of research. Nine scientific sessions will be held on the following topics: 1) Metabolic Pathways leading to Oxalate Formation; 2) Handling of Oxalate/Precursors by Cells; 3) Calcium Oxalate Crystallization Processes; 4) Calcium Oxalate Crystal Inhibition; 5) Crystal and Cell Interactions; 6) Cellular Responses to Oxalate and Calcium Oxalate; 7) Genetic Aspects; 8) Pathophysiology of Stone Disease; 9) Integration of Information from Diverse Systems. The overall goal of this Conference is to provide a forum where a diverse group of scientists in calcium oxalate research can gather and share the broad scope of knowledge among the completely different scientific disciplines. No where else can a botanist, a urologist, and a chemical engineer, (to name just three of the fifteen disciplines represented) gather at the same venue to discuss the same topic each from his/her own point of view. In our view the hallmark of this Conference is underscored by the final program session which acknowledges that collectively we can learn from each other by bringing a multidiscipinary approach to scientific discussion and experimentation.