Harnessing the Melanocortin System (MCS) to moderate inflammation and enhance healthy ageing

利用黑皮质素系统 (MCS) 缓解炎症并促进健康老龄化

• 批准号: 2096137
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2096137
• 关键词: Harnessing; Melanocortin; System; MCS; moderate

Inflammation is an evolutionary conserved biological response in mammals characterised by cell recruitment and release of critical chemokines/cytokines, growth factors and peptide hormones that orchestrate the protective reaction and lead to resolution and tissue repair. Two major cell types that coordinate these responses are macrophages and fibroblast. With age inflammation become prolonged and fails to resolve. The melanocortins have critical roles in regulating inflammation by modulating cell recruitment, adhesion and cytokine release. This project will explore the melanocortin pathways in inflammation and discover the key receptors and ligands that mediate the inflammatory function of macrophages and theirinteraction with fibroblast.

炎症是哺乳动物中进化保守的生物反应，其特征在于细胞募集和释放关键的趋化因子/细胞因子、生长因子和肽激素，其协调保护性反应并导致消退和组织修复。协调这些反应的两种主要细胞类型是巨噬细胞和成纤维细胞。随着年龄的增长，炎症变得延长，无法解决。黑皮质素通过调节细胞募集、粘附和细胞因子释放在调节炎症中具有关键作用。本项目将探索炎症中的黑皮质素通路，并发现介导巨噬细胞炎症功能及其与成纤维细胞相互作用的关键受体和配体。

项目成果

Senescence under appraisal: hopes and challenges revisited.

• DOI: 10.1007/s00018-020-03746-x
• 发表时间: 2021-04
• 期刊: Cellular and molecular life sciences : CMLS
• 作者: Davan-Wetton CSA;Pessolano E;Perretti M;Montero-Melendez T
• 通讯作者: Montero-Melendez T

Melanocortin therapies to resolve fibroblast-mediated diseases.

黑色皮质素疗法可以解决成纤维细胞介导的疾病。

• DOI: 10.3389/fimmu.2022.1084394
• 发表时间: 2022
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: Khodeneva, Natalya;Sugimoto, Michelle A.;Davan-Wetton, Camilla S. A.;Montero-Melendez, Trinidad
• 通讯作者: Montero-Melendez, Trinidad