Conference:Molecular Biophysics of Cellular Membranes

描述（由申请人提供）：我们为FASEB夏季会议“细胞膜的分子生物物理学”寻求部分资助，该会议将于2002年7月13日至18日在佛蒙特州萨克斯顿河的佛蒙特学院举行。这将是正在进行的系列会议的第七次会议，第一次会议于1988年举行。由于这些会议的长期和成功的历史，我们也要求为预计在2004年和2006年举行的会议提供资金。当然，这些年的资金将取决于FASEB是否继续进行该系列研究，以及NIGMS工作人员的有利审查。基因组数据库中现有的序列信息表明，在所有物种中都有大量的基因专门用于膜蛋白的规范。由于众所周知的与膜蛋白的溶解性、稳定性和纯化相关的困难，膜蛋白及其脂质环境对结构生物学、生物化学、生物物理学、生理学和细胞生物学的研究进展缓慢。新的方法和想法对于取得进一步进展至关重要。本次会议将讨论应用生物物理学和生物物理化学的思想来解决膜生物学中具有挑战性的问题。很少有会议像过去的会议那样深入和严谨地讨论这个问题，并计划在未来的会议上进行。与上次会议（2000年）一样，本次会议将围绕一系列适时主题的问题进行组织。通过提供一个深入研究膜生物学基本思想的场所，为刚刚进入该领域的年轻科学家的教育创造了一个环境，也为更资深的科学家的思维发展创造了一个环境。重点将放在使用定量方法来理解结构和机制。专注于具体问题的详细和定量分析，可以说是阐明细胞膜功能和功能失调背后的一般原理的最重要途径。

DESCRIPTION (provided by applicant): We seek partial funding for a FASEB Summer Conference entitled "Molecular Biophysics of Cellular Membranes," which will be held on 13-18 July 2002 at the Vermont Academy in Saxtons River, Vermont. This will be seventh conference of an on-going series, the first of which was held in 1988. Because of the long and successful history of these conferences, we also request funding for conferences anticipated in 2004 and 2006. Funding for these years will, of course, be contingent upon continuation of the series by FASEB and favorable review by NIGMS staff.Sequence information now available in genomic databases indicates that there are a large number of genes in all species devoted to the specification of membrane proteins. Because of the well-known difficulties associated with their solubility, stability, and purification, membrane proteins and their lipid environment have yielded only slowly to the tools of structural biology, biochemistry, biophysics, physiology, and cell biology. New approaches and ideas are essential for further progress. This conference will address the subject of applying ideas from biophysics and biophysical chemistry to challenging problems in membrane biology. Few meetings approach the subject with the depth and rigor that has characterized past meetings, and is planned for future meetings. As in the previous meeting (2000), the conference will be organized around a series of questions on timely topics.By providing a venue for a deep treatment of fundamental ideas in membrane biology, an environment is created for the education of young scientists just entering the field, as well as for the development of thinking by more senior scientists. The emphasis will be on the use of quantitative approaches to understanding structure and mechanism. A sharp focus on detailed and quantitative analyses of specific problems is arguably the most important pathway toward elucidation of general principles that underlie cellular membrane function--and misfunction.