2002 Gordon Research Conf. on Intermediate Filaments

2002 年戈登研究会议。

• 批准号: 6508240
• 负责人: Pierre Coulombe
• 金额: $ 1.5万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-30 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6508240
• 关键词: biomechanics; intermediate filaments; meeting /conference /symposium; molecular biology; protein structure function; structural biology; travel

DESCRIPTION (provided by applicant): The purpose of this application is to generate funds to support travel, registration, and lodging for participants in the 7th Gordon Research Conference on Intermediate Filaments, which will be held June 30th-July 5th 2002 at Roger Williams University in Bristol, Rhode Island. Intermediate filaments (IFs) are prominent components of the cytoskeleton and nuclecoskeleton in higher eukaryotes. In the public draft of the human genome, there are greater than 67 functional genes encoding IF-forming polypeptides. These genes are typically regulated in a cell type-specific manner and highly conserved in mammalian genomes. A general function of IF polymers is to endow cells and tissues with the mechanical resilience they need to withstand various types of physical and non-physical stresses. Defects in IF proteins underlie a vast number of genetically determined fragility disorders involving epithelia (e.g., skin, oral, and eye blistering diseases; inflammatory bowel diseases; liver disorders), muscle (e.g., cardiomyopathies; muscular dystrophy), neural tissue (e.g., amyotrophic lateral sclerosis; Alexander's diseases), and even adipose tissue (e.g., lipodystrophy). IFs fulfill other functions in a differentiation and context-dependent fashion, including promoting specific cytoarchitecture, tissue response to injury and other forms of stress, response to apoptotic signals, signaling, and nuclear architecture and gene expression (lamins). This Gordon Research Conference (GRC) is said to represent the only regular meeting devoted to IF biology. It brings together participants of junior and senior rank from all over the world who are studying IFs from a wide variety of angles. This GRC has traditionally fostered a free-flowing exchange of novel ideas, tools, and reagents, and facilitated the establishment of productive collaborations. The Program for the 2002 edition of the Conference has been finalized. The following major themes will be covered: 1) Atomic structure of IFs: From models to reality; 2) Regulating IF assembly and dynamics in vivo; 3) IFs and cell and tissue mechanics; 4) IF-associated cytolinkers: Mechanical integration and other functions; 4) Function of IFs in C. elegans, in muscle and neurons; 5) Functions of keratins in epithelia: Beyond scaffolding?; and 6) Laminopathies, lamin functions, and the nuclear envelope. In addition, there will be a special "Perspectives" session and a platform session dedicated to the discussion of posters.

描述（由申请人提供）： 本申请的目的是筹集资金，以支持第七届戈登中间纤维研究会议的与会者的旅行、注册和住宿，该会议将于2002年6月30日至7月5日在罗得岛布里斯托的罗杰威廉姆斯大学举行。中间丝是高等真核生物细胞骨架和核骨架的重要组成部分。在公开的人类基因组草图中，有超过67个编码IF形成多肽的功能基因。这些基因通常以细胞类型特异性方式调节，并且在哺乳动物基因组中高度保守。IF聚合物的一般功能是赋予细胞和组织所需的机械弹性，以承受各种类型的物理和非物理应力。 IF蛋白的缺陷是大量涉及上皮的遗传决定的脆性疾病的基础（例如，皮肤、口腔和眼睛起泡疾病;炎性肠病;肝病），肌肉（例如，心肌病;肌营养不良），神经组织（例如，肌萎缩侧索硬化;亚历山大病），甚至脂肪组织（例如，脂肪营养不良）。IF以分化和环境依赖的方式实现其他功能，包括促进特定的细胞结构、对损伤和其他形式的应激的组织反应、对凋亡信号的反应、信号传导以及核结构和基因表达（核纤层蛋白）。 戈登研究会议（GRC）被认为是唯一一次专门讨论IF生物学的定期会议。它汇集了来自世界各地的初级和高级参与者，他们从各种角度研究国际单项体育联合会。传统上，这个GRC促进了新思想、工具和试剂的自由交流，并促进了富有成效的合作的建立。2002年会议的日程已经最后确定。本课程将涵盖以下主题：1）IFs的原子结构：从模型到现实; 2）调节体内IFs组装和动力学; 3）IFs与细胞和组织力学; 4）IFs相关的细胞连接物：机械整合和其他功能; 4）IFs在C. 5）角蛋白在上皮细胞中的功能：超越支架？核纤层病、核纤层蛋白功能和核被膜。此外，将有一个特别的“视角”会议和一个平台会议，专门讨论海报。