2022 Intermediate Filaments Gordon Research Conference and Seminar

2022年中间长丝戈登研究会议暨研讨会

• 批准号: 10469043
• 负责人: Jan Lammerding
• 金额: $ 3.37万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469043
• 关键词: Acute; Address; Affect; Aging; Area; Basic Science; Biological Markers; Biology; Biomedical Engineering; Biophysics; Brain; Bulla; COVID-19 pandemic; Cell Aging; Cell Nucleus; Cell Shape; Cell physiology; Cells; Cellular biology; Chronic; Clinic; Clinical; Collaborations; Columbidae; Communities; Cytoskeleton; DNA biosynthesis; Desmin; Discipline; Disease; Educational workshop; Environment; Fees; Filament; Fostering; Functional disorder; Funding; Future; Gene Family; Gene Mutation; Genes; Genetic Transcription; Goals; Growth; Health; Heart; Human; Immunity; Inflammation; Inflammatory; Intermediate Filament Proteins; Intermediate Filaments; International; Keratin; Knowledge; Lamin Type A; Lead; Link; Location; Malignant Neoplasms; Mechanics; Medicine; Mentors; Mentorship; Muscle; Muscular dystrophy cardiomyopathy; Mutation; Nerve; Neurodegenerative Disorders; Normal Cell; Organ; Participant; Pathogenicity; Patients; Physiological; Play; Premature aging syndrome; Protein Family; Public Health; Request for Applications; Research; Research Personnel; Resistance; Role; Running; Schedule; Scientist; Selection Criteria; Signal Transduction; Skeletal Muscle; Skin; Structural Protein; Students; Talents; Therapeutic; Therapeutic Intervention; Thinking; Time; Tissues; Translating; Underrepresented Minority; Virus Diseases; Woman; base; biological adaptation to stress; biological systems; bone; career; cell motility; extracellular; genetic regulatory protein; graduate student; human disease; insight; interest; lectures; mechanotransduction; meetings; member; microbial; nanoscale; novel; novel therapeutic intervention; posters; programs; recruit; response; sensor; skin disorder; social; structural biology; success; symposium; synergism; translational scientist

Summary Intermediate filament (IF) proteins are encoded by ≈65 distinct genes, placing them among the largest gene families in humans. Members of the IF protein family not only serve as critical components of the cytoskeleton and nucleoskeleton, but also act as sensors, modulators, and integrators of key structural and regulatory proteins. Mutations in genes encoding IF proteins cause a wide range of diseases, including blistering skin diseases, muscular dystrophy, cardiomyopathy, premature aging syndromes, and neurodegenerative disorders. IFs and their abnormal assemblies are hallmarks of and important biomarkers for neurodegenerative diseases, cancer, and aging. The first therapeutic interventions based on research on IF proteins are now starting to benefit patients, yet many questions remain regarding both their basic functions and pathogenic roles in disease. Given the diverse functions of IFs, their interactions with other cellular components, and their disease relevance, close collaborations between basic researchers and clinical/translational investigators spanning multiple disciplines are necessary to overcome current challenges in the field. Bringing together such diverse scientists will provide new insights into the physiological function of IFs and enable developing novel therapeutic approaches for IF-related diseases. Towards this goal, this application requests funds to support the 2022 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on IFs to be held at Mount Snow, West Dover, VT, in June of 2022. We have organized a stimulating program of scientific sessions in an environment that is conductive to concentrated discussion and debate to both established scientists and young investigators/trainees from diverse backgrounds representing multiple disciplines. Aim 1 is to provide an interdisciplinary forum for the discussion of cutting-edge research on IFs and their relationship to normal cellular functions and disease. Aim 2 is to highlight novel scientific themes of IF research through seminar sessions led by leaders in the field and relevant talks by investigators outside the field. Aim 3 is to promote formal and informal scientific exchanges on IF biology between investigators across the entire career spectrum, including senior, mid-career and early-stage scientists, postdoctoral researchers, and graduate students. Graduate students and postdoctoral researchers will also be able to participate in the GRS immediately prior to the GRC. The GRS is run solely by graduate students and postdoctoral researchers studying IFs. To enhance interactions, each day of the GRC and GRS will provide numerous opportunities for informal exchanges among participants, including shared meals, free afternoons, poster sessions, and evening social times. The broad long-term objectives of the GRC and GRS are to grow the IF community, and to provide complementary forums for the exchange of ideas among scientists at all career stages interested in IFs, a family of proteins that are currently understudied despite their significant impact on many areas of public health.

概括 中间丝 (IF) 蛋白由约 65 个不同的基因编码，使它们成为最大的基因之一 人类中的家庭。 IF 蛋白家族的成员不仅是细胞骨架的关键组成部分 和核骨架，但也充当关键结构和调节的传感器、调节器和集成器 蛋白质。编码 IF 蛋白的基因突变会导致多种疾病，包括皮肤起泡 疾病、肌肉萎缩症、心肌病、早衰综合症和神经退行性疾病 失调。 IF 及其异常组装是神经退行性疾病的标志和重要生物标志物 疾病、癌症和衰老。第一个基于 IF 蛋白研究的治疗干预措施现已推出 开始使患者受益，但关于其基本功能和致病性仍然存在许多问题 在疾病中的作用。鉴于 IF 的多种功能、它们与其他细胞成分的相互作用以及它们的作用 疾病相关性、基础研究人员和临床/转化研究人员之间的密切合作 为了克服该领域当前的挑战，需要跨越多个学科。汇集这样的 不同的科学家将为 IF 的生理功能提供新的见解，并能够开发新的 IF 相关疾病的治疗方法。为了实现这一目标，本申请请求资金支持 2022年关于IF的戈登研究会议（GRC）和戈登研究研讨会（GRS）将于 2022 年 6 月，佛蒙特州西多佛尔山雪山。我们组织了一系列激动人心的科学会议 在有利于知名科学家和学者进行集中讨论和辩论的环境中 来自不同背景、代表多个学科的年轻研究者/实习生。目标 1 是提供一个 讨论 IF 及其与正常关系的前沿研究的跨学科论坛 细胞功能和疾病。目标 2 是通过研讨会突出 IF 研究的新颖科学主题 会议由领域内领导主持，相关会谈由领域外调查人员主持。目标3是促进 整个职业生涯中研究人员之间关于 IF 生物学的正式和非正式科学交流 范围，包括高级、职业中期和早期科学家、博士后研究人员和研究生 学生。研究生和博士后研究人员也将能够参加 GRS 紧接在 GRC 之前。 GRS 仅由研究生和博士后研究人员管理 学习 IF。为了加强互动，GRC 和 GRS 的每一天都将提供大量机会 参与者之间的非正式交流，包括共享餐食、下午自由活动、海报会议和晚会 社交时代。 GRC 和 GRS 的广泛长期目标是发展 IF 社区，并 为各个职业阶段感兴趣的科学家之间的思想交流提供补充论坛 IF 是一个蛋白质家族，尽管它们对许多公共领域具有重大影响，但目前尚未得到充分研究 健康。