2022 Intermediate Filaments Gordon Research Conference and Seminar

2022年中间长丝戈登研究会议暨研讨会

• 批准号: 10469043
• 负责人: Jan Lammerding
• 金额: $ 3.37万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-10 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469043
• 关键词: Acute; Address; Affect; Aging; Area; Basic Science; Biological Markers; Biology; Biomedical Engineering; Biophysics; Brain; Bulla; COVID-19 pandemic; Cell Aging; Cell Nucleus; Cell Shape; Cell physiology; Cells; Cellular biology; Chronic; Clinic; Clinical; Collaborations; Columbidae; Communities; Cytoskeleton; DNA biosynthesis; Desmin; Discipline; Disease; Educational workshop; Environment; Fees; Filament; Fostering; Functional disorder; Funding; Future; Gene Family; Gene Mutation; Genes; Genetic Transcription; Goals; Growth; Health; Heart; Human; Immunity; Inflammation; Inflammatory; Intermediate Filament Proteins; Intermediate Filaments; International; Keratin; Knowledge; Lamin Type A; Lead; Link; Location; Malignant Neoplasms; Mechanics; Medicine; Mentors; Mentorship; Muscle; Muscular dystrophy cardiomyopathy; Mutation; Nerve; Neurodegenerative Disorders; Normal Cell; Organ; Participant; Pathogenicity; Patients; Physiological; Play; Premature aging syndrome; Protein Family; Public Health; Request for Applications; Research; Research Personnel; Resistance; Role; Running; Schedule; Scientist; Selection Criteria; Signal Transduction; Skeletal Muscle; Skin; Structural Protein; Students; Talents; Therapeutic; Therapeutic Intervention; Thinking; Time; Tissues; Translating; Underrepresented Minority; Virus Diseases; Woman; base; biological adaptation to stress; biological systems; bone; career; cell motility; extracellular; genetic regulatory protein; graduate student; human disease; insight; interest; lectures; mechanotransduction; meetings; member; microbial; nanoscale; novel; novel therapeutic intervention; posters; programs; recruit; response; sensor; skin disorder; social; structural biology; success; symposium; synergism; translational scientist

Summary Intermediate filament (IF) proteins are encoded by ≈65 distinct genes, placing them among the largest gene families in humans. Members of the IF protein family not only serve as critical components of the cytoskeleton and nucleoskeleton, but also act as sensors, modulators, and integrators of key structural and regulatory proteins. Mutations in genes encoding IF proteins cause a wide range of diseases, including blistering skin diseases, muscular dystrophy, cardiomyopathy, premature aging syndromes, and neurodegenerative disorders. IFs and their abnormal assemblies are hallmarks of and important biomarkers for neurodegenerative diseases, cancer, and aging. The first therapeutic interventions based on research on IF proteins are now starting to benefit patients, yet many questions remain regarding both their basic functions and pathogenic roles in disease. Given the diverse functions of IFs, their interactions with other cellular components, and their disease relevance, close collaborations between basic researchers and clinical/translational investigators spanning multiple disciplines are necessary to overcome current challenges in the field. Bringing together such diverse scientists will provide new insights into the physiological function of IFs and enable developing novel therapeutic approaches for IF-related diseases. Towards this goal, this application requests funds to support the 2022 Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on IFs to be held at Mount Snow, West Dover, VT, in June of 2022. We have organized a stimulating program of scientific sessions in an environment that is conductive to concentrated discussion and debate to both established scientists and young investigators/trainees from diverse backgrounds representing multiple disciplines. Aim 1 is to provide an interdisciplinary forum for the discussion of cutting-edge research on IFs and their relationship to normal cellular functions and disease. Aim 2 is to highlight novel scientific themes of IF research through seminar sessions led by leaders in the field and relevant talks by investigators outside the field. Aim 3 is to promote formal and informal scientific exchanges on IF biology between investigators across the entire career spectrum, including senior, mid-career and early-stage scientists, postdoctoral researchers, and graduate students. Graduate students and postdoctoral researchers will also be able to participate in the GRS immediately prior to the GRC. The GRS is run solely by graduate students and postdoctoral researchers studying IFs. To enhance interactions, each day of the GRC and GRS will provide numerous opportunities for informal exchanges among participants, including shared meals, free afternoons, poster sessions, and evening social times. The broad long-term objectives of the GRC and GRS are to grow the IF community, and to provide complementary forums for the exchange of ideas among scientists at all career stages interested in IFs, a family of proteins that are currently understudied despite their significant impact on many areas of public health.

总结 中间丝（IF）蛋白是由大约65个不同的基因编码的，使它们成为最大的基因之一。 人类的家庭IF蛋白家族的成员不仅是细胞骨架的重要组成部分 和核骨架，但也作为传感器，调制器和关键的结构和调节的整合剂， proteins.编码IF蛋白的基因突变会导致多种疾病，包括皮肤起泡 疾病，肌肉萎缩症，心肌病，过早衰老综合征，和神经退行性疾病， 紊乱IF及其异常组装是神经退行性变的标志和重要的生物标志物， 疾病癌症和衰老第一个基于IF蛋白研究的治疗干预措施现在是 开始使患者受益，但关于其基本功能和致病性仍存在许多问题。 疾病中的角色。考虑到IF的多种功能，它们与其他细胞组分的相互作用，以及它们的 疾病相关性，基础研究人员和临床/转化研究人员之间的密切合作 要克服实地目前的挑战，就必须开展跨多个学科的工作。将这些 不同的科学家将为IF的生理功能提供新的见解，并使开发新的 IF相关疾病的治疗方法。为了实现这一目标，本申请要求资金支持 2022年戈登研究会议（GRC）和戈登研究研讨会（GRS）将在 2022年6月，佛蒙特州西多佛的斯诺山。我们组织了一个刺激的科学会议计划 在一个有利于既有科学家又有专家集中讨论和辩论的环境中， 来自不同背景、代表多个学科的年轻调查员/受训人员。目标1是提供一个 讨论关于国际金融机构及其与正常人关系的前沿研究的跨学科论坛 细胞功能和疾病。目标2是通过研讨会突出IF研究的新科学主题 由外地领导人主持的会议和外地调查人员的有关会谈。目标3：促进 在整个职业生涯中，研究人员之间就IF生物学进行正式和非正式的科学交流 包括高级、职业中期和早期科学家、博士后研究人员和研究生 学生研究生和博士后研究人员也将能够参加GRS 在GRC之前。GRS仅由研究生和博士后研究人员管理 研究IF。为了加强互动，GRC和GRS的每一天都将提供许多机会， 参与者之间的非正式交流，包括共享膳食，免费下午，海报会议和晚上 社交时间GRC和GRS广泛的长期目标是发展IF社区， 为所有职业阶段的科学家提供补充论坛， IFs是一个目前研究不足的蛋白质家族，尽管它们对许多公共领域产生了重大影响。 健康