2009 Epithelial Differentiation & Keratinzation

描述（由申请人提供）：戈登上皮分化和角化研究会议的目标是为表皮和上皮生物学前沿的新研究，概念和机会的传播和讨论提供一个刺激的论坛。1979年组织第一次会议的欧文·弗里德伯格（Irwin Freedberg）和伊斯·伯恩斯坦（Is Bernstein）设想建立一个促进临床和基础科学家之间互动的论坛，这已经实现。表皮仍然是一个中心焦点，但随着我们对上皮之间相似性的理解的增长，会议已经发展到包括其他组织和模型。此外，包括研究兴趣在上皮外的科学家提供了洞察力和创新的概念，加深了我们对皮肤生物学的理解，并确定了新的研究领域。2009年的计划反映了这种持续的进化，重点是基因组生物学，干细胞，发育和体内平衡，以及广泛的皮肤疾病的新治疗方法。下一届会议将于2009年6月21日至26日在瑞士的Les diableets /Eurotel Victoria举行，会议的目标是：1)在定义上皮生物学前沿最重要的问题和机遇的长期传统基础上，促进这一领域的互动和讨论；2)进一步发展上皮生物学领域的年轻研究人员和未被充分代表的少数民族科学家；3)确保该领域保持活力，并接受其他领域的概念和进步。为了实现这些目标，2009年会议将汇集国际骨干参与者，包括来自学术界、工业界、临床医生和基础研究人员、青年科学家和资深科学家、皮肤科医生和病理学家、细胞、发育和分子生物学家，在一个有利于自由交流思想的氛围中。主要会议将讨论的主题包括：1)新兴范式；2)干细胞：动员与调控；3)基因组生物学；4)角质细胞与皮肤生物学新认识；5)发育与组织稳态的信号传导；6)复杂的亚细胞过程；7)疾病病理生理学和治疗方法。此外，两场议题上升会议（周二和周四晚上）将突出海报摘要，以确保该计划反映在提交申请和会议之间可能出现的令人兴奋的新主题。若干“青年研究者奖”将颁发给优秀的研究生和博士后水平的报告。这项提议的具体目标是筹集资金，以支持主席、特邀发言者和其他选定与会者的旅费、登记和生活津贴。

DESCRIPTION (provided by applicant): The goal of the Gordon Research Conference on Epithelial Differentiation & Keratinization is to provide a stimulating forum for the dissemination and discussion of new research, concepts and opportunities at the forefront of epidermal and epithelial biology. Irwin Freedberg and Is Bernstein, who organized the first meeting held in 1979, envisioned developing a forum fostering interactions among clinical and basic scientists, which has been realized. The epidermis remains as a central focus, but the Conference has evolved to include additional tissues and models as our understanding of the similarities among epithelia grew. Additionally, inclusion of scientists whose research interests lies outside epithelia provides insight and innovative concepts that deepen our understanding of skin biology and identify new areas of research. The program for 2009 reflects this continuing evolution with a strong emphasis on genome biology, stem cells, development and homeostasis, and novel therapeutic approaches for a broad range of skin diseases. The aims of the next Conference, to be held June 21-26 (2009) at Les Diablerets/Eurotel Victoria in Switzerland, are to: 1) build on a long-standing tradition of defining the most important problems and opportunities at the frontiers of epithelial biology, and facilitating interactions and discussion in this area; 2) further the development of young investigators, and scientists from under-represented minorities, in epithelial biology; 3) ensure that the field remains vibrant and receptive to concepts and advances in other fields. To accomplish these aims, the 2009 Conference will bring together an international cadre of participants including scientists from academia, industry, clinicians and basic researchers, young scientists and senior scientists, dermatologists and pathologists, cell, developmental and molecular biologists in an atmosphere conducive to the free exchange of ideas. The themes to be developed in the Main Sessions include: 1) Emerging Paradigms; 2) Stem cells: Mobilization and Regulation; 3) Genome biology; 4) New Insight into Keratinocyte and Skin Biology; 5) Signaling in Development and Tissue Homeostasis; 6) Complex Sub cellular Processes; and 7) Disease Pathophysiology and Therapeutic Approaches. In addition, two Issues Rising sessions highlighting poster abstracts (Tuesday and Thursday evenings) will ensure that the program reflects exciting new topics that may emerge between submission of this application and the meeting. Several "Young Investigator Awards" will be given to outstanding graduate student and postdoctoral level presentations. The specific goal of this proposal is to generate funds to support the travel, registration and subsistence for chairs, invited speakers and other selected participants.