Biology of Leukocyte Regulatory Receptor

描述（由申请人提供）：本次会议的目标是 突出了分子和细胞生物学方面的进展， 参与免疫细胞的正性和负性调节的受体 功能这些分子含有ITIM（免疫受体酪氨酸基 抑制基序）、ITAM（基于免疫受体酪氨酸的激活基序）或 在胞质结构域中的PI 3-激酶募集序列，包括 IG和C型凝集素超家族的跨膜受体。 他们的 由于家族成员存在于多种白细胞上， 包括T细胞、B细胞、自然杀伤细胞、肥大细胞和单核细胞- 巨噬细胞-树突状细胞。从动物实验遗传缺陷 对于这些受体，很明显，这些分子在 调节自身免疫和保护免受肿瘤，病毒和 细菌病原体会议开始将由博士发表主旨演讲。 杰夫·拉维奇和研讨会将汇集领导人，他们的研究 包括表达、结构、信号转导和 这些受体在先天性和适应性免疫中的生物学功能。这 是第一次将研究人员聚集在一起， 白细胞调节受体的结构、信号传导和体内生物学 功能

DESCRIPTION (provided by applicant): The goal of this conference is to highlight progress in the molecular and cellular biology for a novel class of receptors that are involved in positive and negative regulation of immune cell function. These molecules contain either ITIM (immune receptor tyrosine-based inhibition motif), ITAM (immune receptor tyrosine- based activation motif) or PI3-kinase recruiting sequences in the cytoplasmic domains and include transmembrane receptors of the Ig- and C-type lectin superfamily. Their expression is broad since family members are found on a variety of leukocytes, including T cells, B cells, natural killer cells, mast cells, and monocyte- macrophage-dendritic cells. From experiments in animals genetically deficient for these receptors, it is clear that these molecules are important in the regulation of autoimmunity and in protection against tumors, viruses and bacterial pathogens. The conference will begin with a keynote address by Dr. Jeff Ravetch and the symposium will bring together leaders whose studies include analysis of the expression, structure, signal transduction and biological functions of these receptors in innate and adaptive immunity. This represents the first conference to bring together investigators with a focus on structure, signaling, and in vivo biology of Leukocyte Regulatory Receptor function.